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Chunk #21 — STUDIES OF RESTING STATE RELATIONSHIPS IN OLDER CHILDREN

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The development of human functional brain networks.
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yes

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Several ICA studies in older children have focused on the DMN. Thomason et al. used group ICA in 9–12 year olds to identify a default-like component that included PCC, MPFC, and bilateral lateral parietal regions, and produced a seed correlation map from PCC that mimicked the default-like component structure (Thomason et al., 2008). Supekar et al. also used ICA to identify a similar default-like component in cohorts of 7–8 and 19–22 year olds (Supekar et al., 2010). This study found significant and increasing partial correlations between PCC and MPFC over development, but minimal partial correlations between PCC and bilateral medial temporal lobe (MTL) in children, which became very weak partial correlations in adults. An additional study by Stevens et al. used ICA/PCA analyses to define 13 components in subjects ages 12–30 years, several of which resembled the default mode network, but since group ICA was performed on all subjects at once, it is unclear to what extent component structures reflect patterns found in children, adolescents, or adults (Stevens et al., 2009).