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Chunk #20 — STUDIES OF RESTING STATE RELATIONSHIPS IN OLDER CHILDREN

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The development of human functional brain networks.
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Partially consistent findings were reported by Kelly et al., who studied correlation maps from 5 sequential seeds placed along the anterior cingulate (thought to participate in 5 different functional domains) in cohorts ages 9–13, 13–17, and 20–24 years (Kelly et al., 2009). Correlation maps in the youngest cohort displayed diffuse correlations near seed locations and few long-distance correlations. Over adolescence, however, correlations proximal to seeds tended to weaken, and correlations at long distances began to emerge, consistent with previous reports of functional connectivity development (Fair et al., 2007a). This pattern was most pronounced in ventral cingulate seeds (classically placed in the DMN), and least pronounced in dorsal seeds near the supplementary motor area (SMA). In particular, and in contrast to the findings of Fair et al. (Fair et al., 2008), Kelly et al. reported a complete absence of anterior-posterior midline correlations from ventral cingulate seeds in their youngest cohort, which increased over development to form full default-like correlation maps in adults.