Chunk #28 — DISCUSSION

Source

Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex.

Embedded

yes

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occur in an RNAi-mediated knockdown over a period of 72 h. For example, expression of other GAPs such as TBC1D15 or Armus may increase to mitigate some of the effects of TBC1D5 KO, but may not do so in the context of a knockdown.