DALRD3 mutation provides an avenue to explore additional biological pathways that are key to proper neurological function and perturbed in neurological disorders. Future experiments will investigate the role of DALRD3 and its associated tRNA modifications in protein translation to identify cellular pathways that would be affected by the m3C modification and their roles in cell physiology and development. An increased understanding of the genetic and molecular underpinnings of early-onset epileptic encephalopathies will be especially vital since many types of these epilepsies are resistant to standard conventional epilepsy therapy65.
