The liver is a predominant organ for the metabolism of alcohol and lipids [24]. It is generally accepted that in the pathogenesis of AFLD, alcohol, as the “first strike,” causes the disorder of lipid metabolism and the heterotopic deposition of triglycerides in hepatocytes. The reaction between reactive oxygen species (ROS) and accumulated triglycerides in hepatocytes is lipotoxic and acts as the “second strike” in the AFLD process [25]. However, how the complement system is involved in this process remains unclear.
