Behavioral responses to acute alcohol exposure in iMOs and humans are also conserved overall (Devineni and Heberlein, 2013; Rothenfluh et al., 2014). Low doses of alcohol elicit locomotor or psychomotor stimulation, while moderate doses of alcohol produce sedation in flies, worms, and humans. Tolerance to alcohol (a blunted effect of the drug after prolonged or repeated exposure) is also observed in both iMOs and humans. A number of assays for measuring the effects of alcohol on behavior have been described for both flies and worms.
