Separate analyses on the sexes in the total sample showed different point estimates for men and women with increased point estimates in men for both neuroticism and extraversion and a decreased point estimate in women for extraversion, however, the genotype-by-sex interaction analysis suggested that these differences were not significant (Supplementary Information Table S2). The estimate of genetic variance from the total sample reflects a weighted average of the estimates of variance from each of the sex cohorts and the covariance tagged by SNPs between the sexes. The nonsignificant genotype-by-sex interaction implies no significant differences between the genetic variances for each sex and the covariance between sexes.
