Chunk #17 — 3. Results — 3.3 A CB1 receptor mechanism of action mediates the reduction of marble burying caused by FAAH and MAGL inhibitors

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Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.

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Finally, the possible role of the CB1 receptor in benzodiazepine suppression of marble burying was tested. Diazepam (1 mg/kg) reduced marble burying [F(1,41) = 44.03; p < 0.0001; Figure 3E], however, rimonabant pretreatment had no effect on diazepam suppression of marble burying (p = 0.58). Neither diazepam nor rimonabant affected locomotor activity (p = 0.65; Figure 3F).