Chunk #16 — 3. Results — 3.3 A CB1 receptor mechanism of action mediates the reduction of marble burying caused by FAAH and MAGL inhibitors

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Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.

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Similarly, JZL184 (16 mg/kg) reduced marble burying [F(1,44) = 11.4; p < 0.01; Figure 3C] and rimonabant prevented this reduction in marble burying. Neither JZL184 nor rimonabant affected immobility (p = 0.60; Figure 3D).