The anxiolytic-like effects of eCBs and exogenous cannabinoids have been previously shown to occur via the CB1 receptor, although the possible role of CB1 in marble burying is unknown. As reported above, PF-3845 (10 mg/kg) reduced marble burying [F(1,43) = 14.2; p < 0.001; Figure 3A], and rimonabant pretreatment blocked this reduction in marble burying. None of the treatments affected locomotor activity (p = 0.38; Figure 3B).
