Chunk #14 — 3. Results — 3.2 Inhibition of eCB catabolic enzymes attenuates anxiety-like behavior in the marble burying test

Source: Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
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The selective MAGL inhibitor JZL184 significantly reduced marble burying [F(3,28) = 46.3; p < 0.0001; Figure 2C] at doses of 16 and 40 mg/kg. However, 40 mg/kg JZL184 also caused a statistically significant increase in immobility [F(57,532) = 2.26; p < 0.0001; Figure 2D]. Unlike THC or diazepam treatment, however, this decrease in locomotor activity did not manifest until after 10 min in the test apparatus.