Since their introduction two years ago, the number of GO-CAMs has increased to over 2838. 533 of these GO-CAMs contain at least one causal relation between activities, linking them into pathways. We are focusing effort on these pathway-oriented GO-CAMs, and expect this number to rise rapidly. A number of model organism databases, including members of the Alliance of Genome Resources (Alliance) (8) and Xenbase (9), are now generating GO-CAMs. In addition, we have initiated a phased project to migrate all standard manual GO annotations generated by Alliance member groups to GO-CAM starting with WormBase (10) and MGI (11). These standard GO annotations will be imported as gene-centric GO-CAMs, gathering all the curator-generated statements about gene function in a single model. The migrated standard GO annotations are also being checked against the ShEx schema to ensure compliance with the GO-CAM model. Going forward, these groups will curate GO-CAMs as their primary product. Users can now access the GO-CAM repository directly from the GO homepage.
