Led by the Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, the SynGO consortium is an international collaboration between 15 laboratories and GO to improve the curation of synapse biology. The project led to the revision of the GO ontology: the synapse branch of the GO Cellular Component aspect was expanded from 13 terms to 129 terms, and the synaptic signaling (GO:0099536) branch of the GO Biological Process aspect was expanded from 42 terms to 256 terms. In addition, SynGO produced over 6500 manual annotations to over 1100 distinct gene products supported by experimental results (12). More than half of these annotations are to mouse proteins, with most of the remainder to rat or human proteins, all of which were subsequently reviewed by the team at CNCR-VU and University College London.
