Using data from a large Israeli household sample containing information about a broad range of TE, this study tested associations between TE, PTSD, and substance (alcohol, nicotine, marijuana) dependence, and examined whether TE is significantly associated with each type of substance dependence after accounting for PTSD. This study advances the extant research by examining associations between TE, PTSD symptoms, and various types of substance dependence within a single study that uses a mixed gender population-based sample with potentially high exposure to traumatic events.