Three loci are located in the vicinity of susceptibility regions for other cancer types. SNP rs11780156 lies ~400 kb downstream of MYC. Previous GWAS have identified multiple loci upstream of MYC that are associated with different cancer types, including a locus for breast cancer. Functional studies have indicated that these associations might be mediated through transcriptional regulation of MYC. The newly associated locus is ~300 kb centromeric to a previously reported susceptibility locus for ovarian cancer, rs10088218, but is uncorrelated with it (r2 = 0.02, based on data from European subjects in BCAC), raising the possibility that these loci might also be regulating MYC33. SNP rs9790517 at 4q24 lies ~20 kb away from SNP rs7679673, previously reported to be associated with prostate cancer34, and is correlated with it (r2 = 0.53). SNP rs9790517 lies in intron 11 of TET2, which encodes a methylcytosine dioxygenase involved in myelopoiesis. Mutations in TET2 are frequent in hematological malignancies but have also been reported in 2 of 47 breast tumors in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. In addition, Pharoah et
