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Chunk #63 — Discussion

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Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.
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yes

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The absence of genetic innovation might be due to a lack of statistical power resulting from the fact that we used a cut-off score of one or more positive answers such that data from the youngest age group (15–17) could be included also, instead of using a cut-off of two or more yes answers as is usually done. In other populations with a low prevalence of AAD a cut-off score of one or more positive answers was also applied (Buchsbaum et al. 1992). More importantly, the cut-off of ≥1 yes answers did not affect the twin correlations or threshold estimates. To fully address the question whether absence of genetic innovation was due to a lack of power since we used the cut-off of ≥1 positive answers, the analyses were repeated using three response categories (0, 1, 2+ yes answers) and four response categories (0, 1, 2, 3+ yes answers) for the age groups spanning from 18 to 32 years. The youngest age group was not included, since in this group the frequency of two or more yes answers was too