We also consider two approaches that attempt to account for this uncertainty. The first of these uses the mean of the distribution of imputed genotypes, which corresponds to an expected allelic or genotypic count, or “dosage”, for each individual. This approach may do well, relative to using the “best guess” genotype, when there is some uncertainty about the true genotype, since it retains more of the available information, differentiating genotypes that were imputed with high confidence from those with greater uncertainty.
