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Chunk #22 — Results — Cis-associations of gene expression with SNPs

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Complex nature of SNP genotype effects on gene expression in primary human leucocytes.
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Gene expression levels for 19,867 transcripts were analyzed for significant genotypic effects at 257,013 autosomal SNPs, mapping within 500 kb of the centre of the transcript probes, resulting in 1,850,599 tests. By using a Spearman's rank correlation coefficient statistic and an FDR of 0.01 or 0.05, 1,360 and 2,178 different SNP-probe effects were detected, respectively. These reflect 394 and 658 unique probes, and 1,273 and 2,035 unique SNPs, respectively (see Table 1).