Alcohol use disorder and related health conditions result from a complex interaction of genetic, neural and environmental factors, with differential impacts across the lifespan. From its inception, COGA has focused on the importance of brain function as it relates to the risk and consequences of alcohol use and AUD, through the examination of noninvasively recorded brain electrical activity and neuropsychological tests. COGA's sophisticated neurophysiological and neuropsychological measures, together with other rich multi‐modal family and longitudinal data, have allowed us to disentangle brain‐related risk and resilience factors from the consequences of prolonged and heavy alcohol use in the context of genomic and social‐environmental influences over the lifespan. COGA has led the field in identifying genetic variation associated with brain functioning, which has advanced the understanding of how genomic risk affects AUD. To date, COGA has amassed an impressive collection of neurophysiological and neuropsychological data on close to 10,000 participants (Table 1) who have also been carefully assessed with diagnostic interviews, behavioral questionnaires, and for whom DNA samples have been collected—all of which are available to the research community. As the complexity
