3365 women from Iceland (P<10−8 in men and P<10−4 in women). Relative to the average recombination rate in the population, each copy of rs3796619 decreased recombination rate by 2.62% in men whereas each copy of the rs1670533 T allele increased recombination by 1.8% in women. The former allele explained 3.5% of the variance in recombination rate in men and the latter allele explained 1.7% of the recombination rate in women.