et al., 2008). In these mice the absence of NMDARs during development led to an increase/decrease in AMPAR EPSCs, presumably due to a form of synaptic scaling (Adesnik et al., 2008). Interestingly in the same DATCre-NR1 mouse behavioral sensitization was abolished when the NMDAR-antagonist AP5 was directly applied into the VTA, implicating NMDARs on non-DA neurons in this behavior (Luo et al., 2010).
