dataset (Figure 5, Table 2)1. Genomic risk for alcohol consumption was significantly predictive of differential expression of CWF19L1 and C18orf8 within the DLPFC of our TWAS replication dataset, in the same direction as was observed in the discovery dataset (Table 2, Supplemental Data). Notably, genetic risk for alcohol consumption was not significantly associated with the expression of any gene in the liver (Figure 5). A phenome-wide association study using the GWAS Atlas revealed evidence that both CWF19L1 and C18orf8 have been implicated in a host of phenotypes, including psychiatric conditions and related traits such as executive function and schizophrenia (CWF19L1), and substance use (C18orf8) (Supplemental Data).
