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Chunk #21 — 3. Results

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Lower Prefrontal and Hippocampal Volume and Diffusion Tensor Imaging Differences Reflect Structural and Functional Abnormalities in Abstinent Individuals with Alcohol Use Disorder.
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on FWER, cortical volume measures with p<0.0022 and subcortical volume measures with p<0.0088 were considered significant. Compared to controls, AUD participants had significantly smaller volume in left parsorbitalis [F=10.73, p<0.002], right medial orbitofrontal [F=10.57, p<0.002], right caudal middle frontal cortices [F=16.60, p<0.0002], and significantly smaller left [F=7.74, p<0.007] and right HV [F=8.16, p<0.006]. Left and right HV had within subject significant correlation (r=0.709, p=4.82×10−10) after controlling for age and ICV. Figures 1b and 2 illustrate the significant volumetric differences between the groups.