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Chunk #42 — ONLINE METHODS — GWAS of subjective well-being

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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
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We performed a sample-size-weighted meta-analysis of the cohort-level summary statistics. To adjust standard errors for non-independence, we inflated them using the square root of the estimated intercept from a LD Score regression10. We also performed secondary, separate meta-analyses of positive affect (N = 180,281) and life satisfaction (N = 166,205) and a post hoc genome-wide analysis of subjective well-being in cohorts with 1000G-imputed data (N = 229,883); see Supplementary Figures 4–6.