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Chunk #17 — RESULTS — Exploring the genomic overlap between externalizing and suicide related outcomes

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A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk.
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Next, we examined the association between MVP-EXT PGS and suicide outcomes (full results in Supplemental Table 10). The MVP-EXT PGS was positively associated with lifetime suicidal ideation and suicide attempt in EUR-like participants from both COGA (Suicidal ideation: OR = 1.18, 95% CI = 1.11, 1.25; Suicide attempt: OR = 1.46, 95% CI = 1.32, 1.61) and Add Health (Suicidal ideation: OR = 1.07, 95% CI = 1.01, 1.13; Suicide attempt: OR = 1.13, 95% CI = 1.03, 1.24), but not the AFR-like participants in either COGA (Suicidal ideation: OR = 0.98, 95% CI = 0.89, 1.08; Suicide attempt: OR = 1.07, 95% CI = 0.94, 1.22) or Add Health (Suicidal ideation: OR = 1.04, 95% CI = 0.93, 1.16; Suicide attempt: OR = 0.97, 95% CI = 0.82, 1.15). For both suicidal ideation and suicide attempt, the meta-analyzed estimate was significant (Suicidal ideation: OR = 1.09, 95% CI = 1.05, 1.13; Suicide attempt: OR = 1.20, 95% CI = 1.13, 1.27). For context, Figure 3, Panel B presents the proportion of respondents in COGA reporting a lifetime suicide attempt