Chunk #19 — Results — Identification of a potent locus associated with human opioid sensitivity by GWAS in subjects who underwent painful cosmetic surgery
final stage with 24-h postoperative fentanyl requirements in the additive and recessive models (additive model: combined β=0.293, nominal P=8.044 × 10−7; recessive model: combined β=0.553, nominal P=9.382 × 10−7; Supplementary Tables S2–4). The observed P-values of these SNPs, calculated as −log10 (P-value), obviously deviated from the expected values from the null hypothesis of uniform distribution in the quantile–quantile plot for the entire sample (Supplementary Figure S2). The genes located in this region were found to include METTL21A (FAM119A) and CREB1, encoding methyltransferase like 21A and cyclic adenosine 3′,5′-monophosphate (cAMP) responsive element-binding protein 1 (CREB1), respectively.
