Our functional genomics efforts continue to accelerate the pace at which genetic discoveries can be placed in a biological context. While gene editing in a cell‐type specific manner and the observation of the functional effects of these changes in organoids are components of our ongoing work, the NIAAA/COGA Sharing Repository as well as continued contact with participants allowing for additional biospecimen collection, sets the stage for experiments tailored to research questions for specific aspects of AUD (e.g., remission) and to developmental periods (e.g., early vs. later life). Furthermore, whole genome sequencing (WGS) methods, especially as their accessibility increases, would substantively improve COGA's ability to study rarer and structural variants, the role of which continues to emerge for psychiatric disorders. A particularly attractive feature of studying rare variation in COGA is its family design, which aids the identification of both private and disorder‐generalized mutations. Similarly, our ability to measure the brain's activity during resting state and during various cognitive tasks with exquisite temporal accuracy, allows us to develop and implement EEG protocols that uniquely address questions regarding the course of AUD.
