Individuals with CUD were identified in the iPSYCH sample through information in the Danish Psychiatric Central Research Register52 as well as in the Danish National Patient Register55 using information up to 2013. All individuals with an ICD10 diagnosis of F12.1-12.9, were included (Supplementary Table 1 and 2). Individuals with acute intoxication (diagnosis code F12.0) were not included among cases (41 individuals had an F12.0 diagnosis; 0.084% of the controls). The F12.0 diagnosis is related to the acute pharmacological effects of cannabis use and resolve with time, and does not necessary reflect long term problematic cannabis use, which is the focus of this study. All individuals in the iPSYCH sample not having a diagnosis of CUD were used as controls and covariates for the major psychiatric disorders studied by iPSYCH were used in the analyses in order to correct for the presence of mental disorders. Only 54 individuals had a diagnosis of CUD and anorexia, and all individuals having a diagnosis of anorexia among cases and the control group were excluded. After QC the study included 2,387 cases and 48,985 in
