Before discussing these results, we would like to note limitations of this study. First, the biomaterial for the studies was provided from lymphoblast cell lines, not serotonergic neurons. However, we have previously shown that these cell lines retain transcriptional signatures reflective of their cognate donors [Philibert et al., 2007b,c]. Second, the IAS subjects are an epidemiologically sound, but high-risk population that is largely white. Therefore, generalizations to other populations should be done judiciously.
