Comparison of the 13 top SNPs from the present study and the COGA, SAGE, and OZ-ALC, showed that four of these 13 SNPs had shown nominal significance in the COGA study (Table 2). Three of these SNPs were in the ADH gene cluster, including the SNP with genome wide significance (Table 1). The fourth SNP, rs9825310, is located intergenically on chromosome 3. The closest RefSeq gene to rs9825310 is the glycerol-3-phosphate dehydrogenase 1-like (GPD1L) gene (OMIM MIM ID *611778), which is located at a distance of ∼30kb. In humans, mutations in the GPD1L gene have been reported to cause Brugada syndrome 2, which is a progressive disorder of myocardial conduction (OMIM MIM ID #611777). Interestingly, this gene has received support for the phenotype “alcohol stimulated activity” in the mouse (Palmer, Lessov-Schlaggar, Ponder et al. 2006), as it is located in the QTL Etact2 on mouse chromosome 9 (http://bioinfo.mc.vanderbilt.edu/ERGR/qtlds.php?qtl=Etact2).
