In addition to the NR3C1 gene, a number of other genes show a significant number of RDme and are induced in response to differences in maternal care. We observed a broad genomic region that shows a cluster-wide response in DNA methylation and expression and exhibits the highest number of RDme relative to other regions in the locus: the -α, -β, and -γ protocadherin (Pcdh) gene clusters (82 of 696 RDme; P = 0.006, permutation test). Among Low LG offspring, we observed a significant enrichment for hypermethylated RDme across the entire Pcdh gene cluster (45 of a total of 350 RDme hypermethylated in Low LG offspring were found within the Pcdh gene clusters; P = 0.01, permutation test).
