We obtained summary association results from deCODE genetics for 1,228 index SNPs (P < 1×10−5) based on 1,979 cases and 142,626 controls of European ancestry. Genotyping was carried out at deCODE Genetics. We used this sample to establish that SNP associations from the primary GWAS replicated en masse in an independent sample (see Supplementary Note) by showing the directions of effect of index SNPs differed from the null hypothesis of randomly oriented effects and also comparing the expected number of same direction effects with those if all associations were true, taking into account the discovery magnitude of effect, and the replication effect-estimate precision (Supplementary Note).
