For AA participants, an ancestry-matched GWAS similar to the one utilized in those of European ancestries is currently unavailable. Thus, we derived the PGS based on the weights from the discovery GWAS of European ancestry individuals (Karlsson Linnér et al., 2021). We recognize the limitation of this approach, particularly in view of prior evidence that PGS are most predictive when individuals in the discovery GWAS and the target sample are matched on ancestral background (Martin et al., 2017; Peterson et al., 2019); the Discussion section further elaborates on these issues.
