file 1: Table S1) and The Dominantly Inherited Alzheimer Network (DIAN; 19 carriers of mutations in APP, PSEN1, PSEN2) (Table 1; Fig. 1). We employed the same pipeline to process all of the samples in order to avoid any bias. Furthermore, RNA-seq from the Knight-ADRC and DIAN studies allowed us to compare the cell composition from ADAD vs LOAD brains, and similarly to test for differences in brains of controls, sporadic AD who do not carry any known high-risk variant, carriers of high-risk variants in TREM2 (n = 20), PLD3 (n = 33), and APOE ε4 allele.
