Chunk #12 — METHODS — Nicotine Dependence and Smoking Phenotypes

Source

CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

Embedded

yes

Text

CPD is an alternative phenotype for smoking behavior that has been studied in previous GWAS. To evaluate CPD, a four point ordinal scale was created: at most 10 cigarettes daily, 11 to 20 cigarettes daily, 21 to 30 cigarettes daily, and more than 30 cigarettes daily. This phenotype has been used in other studies(10). We used this to further examine our top GWAS finding.