All SNPs in LD ( > 0.6) with one of the independent significant SNPs were used in annotation. Functional consequences were obtained by performing ANNOVAR gene-based annotation using Ensembl genes. In addition, potential regulatory functions are indicated by the RegulomeDB score43 (with lower scores indicating a higher probability of having a regulatory function) and by 15-core chromatin states predicted by ChromHMM44 for 127 tissue/cell types45.
