The role of oxytocin in alcohol and drug abuse.
paper
Cited
Public
- Authors
- King, Courtney E; Gano, Anny; Becker, Howard C
- Year
- 2020
- Journal
- Brain research
- PMID
- 32142721
- DOI
- 10.1016/j.brainres.2020.146761
- PMCID
- PMC7137097
The neuropeptide oxytocin (OXT) plays a key role in adaptive processes associated with reward, tolerance, memory and stress responses. Through interactions with brain reward and stress systems, OXT is known to play a role in several neuropsychiatric disorders, particularly those that involve altered social integration, such as alcohol and drug addiction (Heilig et al., 2016). As such, there is growing interest in the oxytocin system as a potential therapeutic target for the treatment of alcohol and substance use disorders. Accumulating preclinical evidence suggests that administration of OXT influences the development of tolerance, sensitization and withdrawal symptoms, and modulates numerous alcohol/drug-seeking and alcohol/drug-taking behaviors. Further, there is some evidence to suggest that OXT may help to reverse neuroadaptations that occur as a result of chronic alcohol or drug exposure. To date, there have been only a handful of clinical studies conducted in alcohol and drug dependent populations. This review summarizes the preclinical and clinical literature on the effects of OXT administration on alcohol- and drug-related behaviors. In addition, we discuss OXT interactions with the hypothalamic-pituitaryadrenal axis and multiple neurotransmitter systems within addiction circuitry.
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| Name | Type |
|---|---|
| accessory magnocellular nuclei local | anatomy |
| Acquisition local | phenotype |
| ACTH | drug |
| acute tolerance | phenotype |
| addiction | phenotype |
| addiction pathology local | phenotype |
| ADRA2A | gene |
| aggression | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| alcohol-dependent rats | cohort |
| alcohol/drug abuse | phenotype |
| alcohol/drug taking behavior local | phenotype |
| alcoholism | phenotype |
| alcohol preference | phenotype |
| Alcohol relapse-like behavior local | phenotype |
| Alcohol reward | phenotype |
| Alcohol seeking | phenotype |
| Alcohol-seeking behavior local | phenotype |
| alcohol self-administration | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| Alcohol users local | cohort |
| alcohol withdrawal | phenotype |
| amphetamine | drug |
| amygdala | anatomy |
| analgesic effect | phenotype |
| anterior olfactory nucleus | anatomy |
| anti-nociceptive effect | phenotype |
| anxiety | phenotype |
| Anxiety (withdrawal-induced) local | phenotype |
| ataxia | phenotype |
| ataxic effect | phenotype |
| AUD | phenotype |
| AVP | drug |
| AVPR1A | gene |
| AVPR1B local | gene |
| AVPR2 local | gene |
| bed nucleus of the stria terminalis | anatomy |
| Binge-like alcohol consumption local | phenotype |
| BNST | anatomy |
| Brain oxytocin system local | anatomy |
| brainstem | anatomy |
| Cannabis-dependent individuals local | cohort |
| cannabis use | phenotype |
| Carbetocin local | drug |
| central amygdala | anatomy |
| cerebral spinal fluid | drug |
| chronic tolerance | phenotype |
| cocaine | phenotype |
| cocaine use disorder | phenotype |
| complex social behaviors local | phenotype |
| compulsive drug taking local | phenotype |
| conditioned place preference | phenotype |
| corticosterone | drug |
| corticotropin-releasing factor | drug |
| Cortisol/DHEAS ratio local | phenotype |
| cortisol response | phenotype |
| craving | phenotype |
| CRF | drug |
| cue-induced reinstatement | phenotype |
| cue reactivity | phenotype |
| Decreased OXT levels local | phenotype |
| Decreased Oxt mRNA expression local | phenotype |
| Decreased OXT synthesis and release local | phenotype |
| Decrease in OXT peptide content local | phenotype |
| dependence | phenotype |
| depression | phenotype |
| Depression (withdrawal-induced) local | phenotype |
| Depressive-related behaviors local | phenotype |
| Desire to use drug local | phenotype |
| dopamine | drug |
| Dopamine D2 receptor | drug |
| dorsal caudate putamen local | anatomy |
| dorsal medial prefrontal cortex | anatomy |
| dorsal striatum | anatomy |
| drug | drug |
| drug dependence | phenotype |
| drug experience | phenotype |
| Drug-primed reinstatement local | phenotype |
| drugs | drug |
| drug-seeking behavior | phenotype |
| Drug seeking reinstatement local | phenotype |
| dysphoria | phenotype |
| early stage of addiction local | phenotype |
| Emotion | phenotype |
| emotionality/mood local | phenotype |
| Enhanced motivation for alcohol local | phenotype |
| Escalated alcohol drinking local | phenotype |
| Executive functioning system local | anatomy |
| extended amygdala | anatomy |
| Extra-hypothalamic stress-related brain regions local | anatomy |
| Female cannabis users | phenotype |
| Female cocaine users local | cohort |
| female mice | cohort |
| female rats | cohort |
| food intake | phenotype |
| Forced-swim stress local | drug |
| forebrain | anatomy |
| Fos | gene |
| Fos protein local | drug |
| GABA | phenotype |
| GABAA receptor | drug |
| Gamma-aminobutyric acid | drug |
| glucocorticoids | drug |
| glutamate | drug |
| habit formation | phenotype |
| heavy drinking | phenotype |
| Heroin-dependent men local | cohort |
| heroin self-administration | phenotype |
| HIPP local | anatomy |
| hippocampus | anatomy |
| HPA axis | anatomy |
| HPA-axis local | phenotype |
| HPA-axis reactivity local | phenotype |
| human postmortem AUD subjects local | cohort |
| hyperactivity | phenotype |
| Hyper-locomotion local | phenotype |
| hypnotic effects local | phenotype |
| Hypothalamic nuclei local | anatomy |
| hypothalamus | anatomy |
| Hypothermic effect | phenotype |
| hypothermic effects local | phenotype |
| Increased Oxt mRNA expression local | phenotype |
| insula | anatomy |
| irritability | phenotype |
| Lactating rats local | cohort |
| lateral septum | anatomy |
| learning and memory | phenotype |
| Lever responding local | phenotype |
| limbic regions | anatomy |
| limbic system | anatomy |
| locomotor hyperactivity | phenotype |
| locus coeruleus | anatomy |
| Maintenance local | phenotype |
| Male alcoholics | phenotype |
| male AUD subjects local | cohort |
| Male cannabis users | phenotype |
| Male cocaine users local | cohort |
| male mice | cohort |
| male rats | cohort |
| maternal behaviors local | phenotype |
| medial prefrontal cortex | anatomy |
| Mesocorticolimbic dopamine system local | anatomy |
| methamphetamine | drug |
| methamphetamine CPP | phenotype |
| Methamphetamine seeking local | phenotype |
| Methamphetamine-seeking local | phenotype |
| Methamphetamine-seeking behavior local | phenotype |
| Mg2+ | drug |
| mGluR2/3 antagonist local | drug |
| mice | cohort |
| Mn2+ | drug |
| morphine | drug |
| Morphine-conditioned place preference local | phenotype |
| Morphine-induced CPP local | phenotype |
| Morphine-primed CPP reinstatement local | phenotype |
| mPFC | anatomy |
| NAc | anatomy |
| naloxone | drug |
| negative affect | phenotype |
| negative reinforcement | phenotype |
| Neuroadaptive tolerance local | phenotype |
| neuroendocrine response | phenotype |
| neuronal excitability | phenotype |
| neuropsychiatric disorders | phenotype |
| nicotine | drug |
| nicotine use | phenotype |
| nondependent | phenotype |
| Nondependent rats local | cohort |
| noradrenaline | drug |
| Noradrenaline release local | phenotype |
| nucleus accumbens | anatomy |
| nucleus of the solitary tract | anatomy |
| Nucleus tractus solitarius local | anatomy |
| Operant alcohol self-administration local | phenotype |
| Opiate dependent rats local | cohort |
| OXT | gene |
| OXT null mice local | cohort |
| OXTR local | drug |
| OXTR | gene |
| OXTR-ADRA2A heterodimer local | variant |
| OXTR antagonist local | drug |
| oxytocin | drug |
| Oxytocin receptor | gene |
| pair bonding | phenotype |
| paraventricular nucleus | anatomy |
| paraventricular nucleus (PVN) | anatomy |
| parturition local | phenotype |
| Patients with dual diagnosis of PTSD and AUD local | cohort |
| PFC | anatomy |
| picrotoxin | drug |
| plasma | anatomy |
| positive reinforcement | phenotype |
| posterior pituitary local | anatomy |
| Postpartum hemorrhage local | phenotype |
| Post-Traumatic Stress Disorder | phenotype |
| prairie voles | cohort |
| Predator odor exposure local | drug |
| prefrontal cortex | anatomy |
| PVN | anatomy |
| rapid tolerance | phenotype |
| rats | cohort |
| Reduction in OXT plasma concentrations local | phenotype |
| Region-specific alterations in brain OXT expression local | phenotype |
| reinstatement | phenotype |
| relapse | phenotype |
| Restraint stress local | drug |
| reward | phenotype |
| Reward behavior local | phenotype |
| Rewarding aspects of alcohol local | phenotype |
| reward pathways | anatomy |
| reward system | anatomy |
| Reward thresholds local | phenotype |
| rodents | cohort |
| sedative effects | phenotype |
| Seizures (picrotoxin-induced) local | phenotype |
| sensitization | phenotype |
| Serum cortisol level local | phenotype |
| social and reward related behaviors local | phenotype |
| Social anxiety behavior local | phenotype |
| social behavior | phenotype |
| sociality local | phenotype |
| social reward processing local | phenotype |
| Somatic measures (withdrawal-induced) local | phenotype |
| SON local | anatomy |
| spinal cord | anatomy |
| Stereotyped behavior local | phenotype |
| stereotyped behaviors local | phenotype |
| stress | phenotype |
| Stressful stimuli local | phenotype |
| Stress-induced craving | phenotype |
| stress-induced glutamate increase local | phenotype |
| stress provocation local | phenotype |
| Stress-related behavior local | phenotype |
| Stress-related behaviors local | phenotype |
| stress-related relapse local | phenotype |
| Stress-related relapse-like behavior local | phenotype |
| stress response | phenotype |
| Stress system local | anatomy |
| Striatal noradrenaline turnover local | phenotype |
| striatum | anatomy |
| Subjective stress local | phenotype |
| substances | phenotype |
| substance use | phenotype |
| subthalamic nucleus | anatomy |
| suckling local | phenotype |
| sucrose | drug |
| supraoptic nucleus local | anatomy |
| Supraoptic nucleus local | anatomy |
| tolerance | phenotype |
| total cholesterol | phenotype |
| Treatment-seeking patients local | cohort |
| Upregulation of OXTR binding local | phenotype |
| Upregulation of OXT receptor density local | phenotype |
| uterine contractions local | phenotype |
| V1b receptor local | gene |
| vasopressin | drug |
| Vasopressin receptor V1a local | gene |
| Vasopressin receptor V1b local | gene |
| Vasopressin receptor V2 local | gene |
| ventral hippocampus | anatomy |
| ventral pallidum | anatomy |
| ventral tegmental area | anatomy |
| VTA | anatomy |
| withdrawal | phenotype |
| Withdrawal-induced seizures local | phenotype |
| withdrawal-related symptoms local | phenotype |
| Withdrawal-related symptoms local | phenotype |
| Withdrawal scores local | phenotype |
| yohimbine | drug |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| RNA alternative splicing impacts the risk for alcohol use disorder. | 2023 | 37217680 |
External
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|---|---|---|---|---|
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| Altered association of plasmatic oxytocin with affective stress response in alcohol use disorder. | Mayer AV et al. | β | 2025 | β |
| Could intranasal oxytocin enhance the effects of psychotherapy in individuals with mental disorders? A systematic review and meta-analysis. | PΓ©rez-Arqueros V et al. | β | 2025 | β |
| Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats. | Faraji M et al. | β | 2025 | β |
| Evaluating the Effect of Oxytocin and Zinc Sulphate on Reproductive Indices in Opiate-Addicted Men Receiving Methadone Maintenance Therapy: A Randomized, Double-Masked Clinical Trial. | Mirzai N et al. | β | 2025 | β |
| Guilt and shame and its relation to oxytocin in patients with depression and alcohol addiction. | Mavrogiorgou P et al. | β | 2025 | β |
| Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers. | Marcus MM et al. | β | 2025 | β |
| Novel potential pharmacological approaches in treating eating disorders comorbid with substance use disorders. | Xi ZX et al. | β | 2025 | β |
| Opioid quantification via microsampling techniques to assess opioid use in human laboratory studies. | Fariha R et al. | β | 2025 | β |
| Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference. | Cheng YJ et al. | β | 2025 | β |
| Oxytocin Reduces Noradrenergic-Induced Opioid-Like Withdrawal Symptoms in Individuals on Opioid Agonist Therapy. | Gully BJ et al. | β | 2025 | β |
| The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review. | Bagosi Z et al. | β | 2025 | β |
| The Relationship Between Oxytocin and Alcohol Dependence. | Schimmer J et al. | β | 2025 | β |
| Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of <i>Anacyclus pyrethrum</i>. | Baslam A et al. | β | 2024 | β |
| Oxytocin as a treatment for alcohol use disorder and heavy drinking: A narrative review. | Rastogi K et al. | β | 2024 | β |
| Patterns of neuronal activation following ethanol-induced social facilitation and social inhibition in adolescent cFos-LacZ male and female rats. | Towner TT et al. | β | 2024 | β |
| Role of oxytocin and vasopressin in alcohol use disorder. | Scarboro SM et al. | β | 2024 | β |
| SNP analysis of stress-related genes reveals significant correlations with drug addiction in Jordan. | Al-Eitan L et al. | β | 2024 | β |
| The interplay of childhood trauma, oxytocin, and impulsivity in predicting the onset of methamphetamine use. | Chang HM et al. | β | 2024 | β |
| Blockade of endocannabinoid system by oxytocin attenuates memory deficits in oxycodone-treated rats. | Wan YX et al. | β | 2023 | β |
| Novel Pharmacological Targets of Post-Traumatic Stress Disorders. | Marazziti D et al. | β | 2023 | β |
| Novel RNA-Seq Signatures Post-Methamphetamine and Oxycodone Use in a Model of HIV-Associated Neurocognitive Disorders. | Athota P et al. | β | 2023 | β |
| Oxytocin in the Treatment of Psychiatric Disorders. | Kagizman SC et al. | β | 2023 | β |
| Oxytocin receptors mediate oxytocin potentiation of methylphenidate-induced stimulation of accumbens dopamine in rats. | Hersey M et al. | β | 2023 | β |
| Oxytocin Reduces Sensitized Stress-Induced Alcohol Relapse in a Model of Posttraumatic Stress Disorder and Alcohol Use Disorder Comorbidity. | Becker HC et al. | β | 2023 | β |
| Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats. | Nett KE et al. | β | 2023 | β |
| RNA alternative splicing impacts the risk for alcohol use disorder | Liu Y et al. | β | 2023 | β |
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| The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review. | Lee-Cheong S et al. | β | 2023 | β |
| Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards. | Dunigan AI et al. | β | 2022 | β |
| A randomized controlled trial examining the effects of intranasal oxytocin on alcohol craving and intimate partner aggression among couples. | Flanagan JC et al. | β | 2022 | β |
| Associations between alcohol use and peripheral, genetic, and epigenetic markers of oxytocin in a general sample of young and older adults. | Rung JM et al. | β | 2022 | β |
| Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review. | Barbee BR et al. | β | 2022 | β |
| Effects of oxytocin administration on fear-potentiated acoustic startle in co-occurring PTSD and alcohol use disorder: A randomized clinical trial. | Stauffer CS et al. | β | 2022 | β |
| Elevated Oxytocin Receptor Blood Concentrations Predict Higher Risk for, More, and Earlier 24-Month Hospital Readmissions after In-Patient Detoxification in Males with Alcohol Use Disorder. | MΓΌhle C et al. | β | 2022 | β |
| Establishment of a biomarker of peripheral stress in opioid addicts based on the hypothalamic-pituitary-adrenal axis-The improvement effect of exercise. | Wang J et al. | β | 2022 | β |
| Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes. | Amato S et al. | β | 2022 | β |
| Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects. | Rae M et al. | β | 2022 | β |
| The oxytocin signaling complex reveals a molecular switch for cation dependence. | Meyerowitz JG et al. | β | 2022 | β |
| Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors. | King CE et al. | β | 2021 | β |
| Alcohol and oxytocin: Scrutinizing the relationship. | Ryabinin AE et al. | β | 2021 | β |
| Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression. | Roschina OV et al. | β | 2021 | β |
| Can intranasal oxytocin reduce craving in automated addictive behaviours? A systematic review. | Houghton B et al. | β | 2021 | β |
| Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size. | Salehi MS et al. | β | 2021 | β |
| Does endogenous cholecystokinin modulate alcohol intake? | Ballaz S et al. | β | 2021 | β |
| Efficacy of Self-Administered Intranasal Oxytocin on Alcohol Use and Craving After Detoxification in Patients With Alcohol Dependence. A Double-Blind Placebo-Controlled Trial. | Melby K et al. | β | 2021 | β |
| Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal. | Ponzoni L et al. | β | 2021 | β |
| Intranasal Oxytocin for Stimulant Use Disorder Among Male Veterans Enrolled in an Opioid Treatment Program: A Randomized Controlled Trial. | Stauffer CS et al. | β | 2021 | β |
| Oxytocin blood concentrations in alcohol use disorder: A cross-sectional, longitudinal, and sex-separated study. | Lenz B et al. | β | 2021 | β |
| Oxytocin, but not arginine-vasopressin neurons project from the hypothalamus to amygdala in human: DiI-based tracing study in postmortem brain. | Sivukhina EV et al. | β | 2021 | β |
| Oxytocin reverses ethanol consumption and neuroinflammation induced by social defeat in male mice. | ReguilΓ³n MD et al. | β | 2021 | β |
| Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward. | Ferrer-PΓ©rez C et al. | β | 2021 | β |
| Roles of Oxytocin in Stress Responses, Allostasis and Resilience. | Takayanagi Y et al. | β | 2021 | β |
| The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use. | Le TM et al. | β | 2021 | β |
| The role of neuropeptides in drug and ethanol abuse: Medication targets for drug and alcohol use disorders. | Barson JR | β | 2020 | β |
| What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience. | Sharma SR et al. | β | 2020 | β |