Genetic influences on alcohol consumption patterns and problem drinking: results from the Australian NH&MRC twin panel follow-up survey.
paper
Cited
Public
Unavailable
- Authors
- Heath, A C; Martin, N G
- Year
- 1994
- Journal
- Annals of the New York Academy of Sciences
- PMID
- 8154691
- DOI
- 10.1111/j.1749-6632.1994.tb24699.x
Self-report questionnaire data from 3,000 adult twin pairs participating in the 1988-1989 follow-up survey of the Australian NH&MRC twin panel were analyzed to determine (1) the contribution of genetic factors to risk of problem drinking in males and females; and (2) the magnitude of the correlation between genetic effects on problem drinking and genetic effects on alcohol consumption level. Significant genetic contributions were found both for average weekly consumption of alcohol and for problem-drinking history. For level of consumption, genetic factors accounted for approximately 58% of the variation in females and 45% of the variation in males. Heritability estimates for problem drinking, though significantly greater than zero, were variable in magnitude, ranging (under different models) from 8-44% in females and 10-50% in males. Likewise, estimates of the magnitude of the genetic correlation, whilst in all cases significantly greater than zero, ranged from 0.42-1.00 in females and 0.45-1.00 in males under different models.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic Architecture and Risk Profile of Alcohol-Related Diseases | Ala-Mutka E et al. | — | 2025 | — |
| Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome. | Salles J et al. | — | 2024 | → |
| Evaluating risk for alcohol use disorder: Polygenic risk scores and family history. | Lai D et al. | — | 2022 | → |
| Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. | Lai D et al. | — | 2022 | → |
| Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse. | Corongiu S et al. | — | 2022 | → |
| Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. | Clarke TK et al. | — | 2021 | → |
| The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample. | Johnson EC et al. | — | 2019 | → |
| A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. | Otto JM et al. | — | 2017 | → |
| Major depressive disorder, suicidal thoughts and behaviours, and cannabis involvement in discordant twins: a retrospective cohort study. | Agrawal A et al. | — | 2017 | → |
| Phenotypic and Genetic Relationship Between BMI and Drinking in a Sample of UK Adults. | Wills AG et al. | — | 2017 | → |
| Role of overlapping genetic and environmental factors in the relationship between early adolescent conduct problems and substance use in young adulthood. | Verweij KJ et al. | — | 2016 | → |
| Metabolic methanol: molecular pathways and physiological roles. | Dorokhov YL et al. | — | 2015 | → |
| The pharmacogenetics of alcohol use disorder. | Jones JD et al. | — | 2015 | → |
| Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample. | Irons DE et al. | — | 2014 | → |
| Heritability of usual alcohol intoxication and hangover in male twins: the NAS-NRC Twin Registry. | Wu SH et al. | — | 2014 | → |
| Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. | Kos MZ et al. | — | 2014 | → |
| Suicidal behavior and haplotypes of the dopamine receptor gene (DRD2) and ANKK1 gene polymorphisms in patients with alcohol dependence--preliminary report. | Jasiewicz A et al. | — | 2014 | → |
| A behavioral genetic investigation of weekend drinking among an adult sample. | Cleveland HH et al. | — | 2013 | → |
| A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. | Wang JC et al. | — | 2013 | → |
| Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| A candidate gene association study of alcohol consumption in young women. | Agrawal A et al. | — | 2011 | → |
| Developing a genetically informative measure of alcohol consumption using past-12-month indices. | Agrawal A et al. | — | 2011 | → |
| Genome-wide association studies of alcohol intake--a promising cocktail? | Agrawal A et al. | — | 2011 | → |
| Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture. | Dick DM et al. | — | 2011 | → |
| Parental depression and offspring psychopathology: a children of twins study. | Singh AL et al. | — | 2011 | → |
| Revisiting the effect of marital support on depressive symptoms in mothers and fathers: a genetically informed study. | Beam CR et al. | — | 2011 | → |
| Breaking barriers in the genomics and pharmacogenetics of drug addiction. | Ho MK et al. | — | 2010 | → |
| Cerebellar lingula size and experiential risk factors associated with high levels of alcohol and drug use in young adults. | Anderson CM et al. | — | 2010 | → |
| The moderating effect of religiosity on the genetic variance of problem alcohol use. | Button TM et al. | — | 2010 | → |
| Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? | Hansell NK et al. | — | 2009 | → |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | — | 2008 | → |
| Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence. | Hansell NK et al. | — | 2008 | → |
| Males do not reduce the fitness of their female co-twins in contemporary samples. | Medland SE et al. | — | 2008 | → |
| A behavior genetic investigation of adolescent motherhood and offspring mental health problems. | Harden KP et al. | — | 2007 | → |
| A Genetically Informed Study of the Intergenerational Transmission of Marital Instability. | D'Onofrio BM et al. | — | 2007 | → |
| Childhood sexual abuse and the course of alcohol dependence development: findings from a female twin sample. | Sartor CE et al. | — | 2007 | → |
| Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? | Morley KI et al. | — | 2007 | → |
| Gene-environment interactions reexamined: does mother's marital stability interact with the dopamine receptor D2 gene in the etiology of childhood attention-deficit/hyperactivity disorder? | Waldman ID | — | 2007 | → |
| Intergenerational transmission of childhood conduct problems: a Children of Twins Study. | D'Onofrio BM et al. | — | 2007 | → |
| Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects? | Grant JD et al. | — | 2007 | → |
| A genetically informed study of the association between harsh punishment and offspring behavioral problems. | Lynch SK et al. | — | 2006 | → |
| A genetically informed study of the processes underlying the association between parental marital instability and offspring adjustment. | D'Onofrio BM et al. | — | 2006 | → |
| A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. | Morley KI et al. | — | 2006 | → |
| Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. | Dickson PA et al. | — | 2006 | → |
| Family structure and age at menarche: a children-of-twins approach. | Mendle J et al. | — | 2006 | → |
| Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). | Lorenz JG et al. | — | 2006 | → |
| A genetically informed study of marital instability and its association with offspring psychopathology. | D'Onofrio BM et al. | — | 2005 | → |
| Correlates of regular cigarette smoking in a population-based sample of Australian twins. | Agrawal A et al. | — | 2005 | → |
| Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins. | Lynskey MT et al. | — | 2005 | → |
| Support for previously identified alcoholism susceptibility Loci in a cohort selected for smoking behavior. | Wilhelmsen KC et al. | — | 2005 | → |
| The genetics of alcohol intake and of alcohol dependence. | Whitfield JB et al. | — | 2004 | → |
| Psychiatric genetics in Australia. | Mowry BJ | — | 2003 | → |
| Adverse childhood experiences and personal alcohol abuse as an adult. | Dube SR et al. | — | 2002 | → |
| Growing up with parental alcohol abuse: exposure to childhood abuse, neglect, and household dysfunction. | Dube SR et al. | — | 2001 | → |
| Aetiology of teenage childbearing: reasons for familial effects. | Olausson PO et al. | — | 2000 | → |
| Possible association between loudness dependence of auditory evoked potentials and tryptophan hydroxylase-alleles in alcoholics. | Preuss UW et al. | — | 2000 | → |
| Electroencephalographic responses to alcohol challenge in Native American Mission Indians. | Ehlers CL et al. | — | 1999 | → |
| The genetics of alcoholism: 1997. | Guze SB | — | 1997 | → |
| Alcohol reactions in subjects of European descent: effects on alcohol use and on physical and psychomotor responses to alcohol. | Whitfield JB et al. | — | 1996 | → |
| Potential barriers to parent monitoring: social disadvantage, marital status, and maternal psychiatric disorder. | Chilcoat HD et al. | — | 1996 | → |
| Is alcohol-related flushing a protective factor for alcoholism in Caucasians? | Slutske WS et al. | — | 1995 | → |