From genotype to EEG endophenotype: a route for post-genomic understanding of complex psychiatric disease?
paper
Cited
Public
- Authors
- de Geus, Eco Jc
- Year
- 2010
- Journal
- Genome medicine
- PMID
- 20828426
- DOI
- 10.1186/gm184
- PMCID
- PMC3092114
Twin and family studies have shown the importance of biological variation in psychiatric disorders. Heritability estimates vary from 50% to 80% for cognitive disorders, such as schizophrenia, attention deficit hyperactivity disorder and autism, and from 40% to 65% for affective disorders, such as major depression, anxiety disorders and substance abuse. Pinpointing the actual genetic variants responsible for this heritability has proven difficult, even in the recent wave of genome-wide association studies. Brain endophenotypes derived from electroencephalography (EEG) have been proposed as a way to support gene-finding efforts. A variety of EEG and event-related-potential endophenotypes are linked to psychiatric disorders, and twin studies have shown a striking genetic contribution to these endophenotypes. However, the clear need for very large sample sizes strongly limits the usefulness of EEG endophenotypes in gene-finding studies. They require extended laboratory recordings with sophisticated and expensive equipment that are not amenable to epidemiology-scaled samples. Instead, EEG endophenotypes are far more promising as tools to make sense of candidate genetic variants that derive from association studies; existing clinical data from patients or questionnaire-based assessment of psychiatric symptoms in the population at large are better suited for the association studies themselves. EEG endophenotypes can help us understand where in the brain, in which stage and during what type of information processing these genetic variants have a role. Such testing can be done in the more modest samples that are feasible for EEG research. With increased understanding of how genes affect the brain, combinations of genetic risk scores and brain endophenotypes may become part of the future classification of psychiatric disorders.
No figures extracted from this document.
1β12 of 12
| Name | Type |
|---|---|
| ADHD | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| anxiety | phenotype |
| atherosclerotic risk local | phenotype |
| attention deficit hyperactivity disorder | phenotype |
| autism | phenotype |
| brain | anatomy |
| brain endophenotype local | phenotype |
| cardiovascular disease | phenotype |
| cerebral hemispheres | anatomy |
| common variants | cohort |
| Crohn's disease | phenotype |
| depression | phenotype |
| diabetes | phenotype |
| EEG | phenotype |
| endophenotype | phenotype |
| ERP | phenotype |
| ERP endophenotypes local | phenotype |
| fear | phenotype |
| frontal asymmetry of EEG Ξ± power local | phenotype |
| frontal cortex | anatomy |
| genetic variants | cohort |
| locus coeruleus | anatomy |
| locus-coeruleus-norepinephrine system local | anatomy |
| major depressive disorder | phenotype |
| mood disorders | phenotype |
| Negative attitudes local | phenotype |
| Netherlands Twin Register | cohort |
| norepinephrine | drug |
| ORP | phenotype |
| P3 amplitude | phenotype |
| psychiatric disorders | phenotype |
| psychiatric risk | phenotype |
| psychiatric symptoms | phenotype |
| psychiatric traits | phenotype |
| rare variant | cohort |
| rejection | phenotype |
| risk allele | cohort |
| schizophrenia | phenotype |
| stigma | phenotype |
| substance abuse | phenotype |
| Twin registries local | cohort |
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AgrawalALynskeyMTThe genetic epidemiology of cannabis use, abuse and dependence.Addiction200610180181210.1111/j.1360-0443.2006.01399.x16696624 | β | β | β |
| AnokhinAPGolosheykinSHeathACHeritability of frontal brain function related to action monitoring.Psychophysiology20084552453410.1111/j.1469-8986.2008.00664.x18503487 | β | β | β |
| AnokhinAPHeathACMyersEGenetics, prefrontal cortex, and cognitive control: a twin study of event-related brain potentials in a response inhibition task.Neurosci Lett200436831431810.1016/j.neulet.2004.07.03615364418 | β | β | β |
| AnokhinAPVedeniapinABHeathACKorzyukovOBoutrosNNGenetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study.Schizophr Res20078931231910.1016/j.schres.2006.08.00917014995 | β | β | β |
| AulchenkoYSRipattiSLindqvistIBoomsmaDHeidIMPramstallerPPPenninxBWJHJanssensACJWWilsonJFSpectorTMartinNGPedersenNLKyvikKOKaprioJHofmanAFreimerNBJarvelinMRGyllenstenUCampbellHRudanIJohanssonAMarroniFHaywardCVitartVJonassonIPattaroCWrightAHastieNPichlerIHicksAALoci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.Nat Genet20094147551906091110.1038/ng.269PMC2687074 | β | β | β |
| BarrettJCHansoulSNicolaeDLChoJHDuerrRHRiouxJDBrantSRSilverbergMSTaylorKDBarmadaMMBittonADassopoulosTDattaLWGreenTGriffithsAMKistnerEOMurthaMTRegueiroMDRotterJISchummLPSteinhartAHTarganSRXavierRJLibioulleCSandorCLathropMBelaicheJDewitOGutIHeathSGenome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.Nat Genet2008409559621858739410.1038/ng.175PMC2574810 | β | β | β |
| CichonSCraddockNDalyMFaraoneSVGejmanPVKelsoeJLehnerTLevinsonDFMoranASklarPSullivanPFGenomewide association studies: history, rationale, and prospects for psychiatric disorders.Am J Psychiatry200916654055610.1176/appi.ajp.2008.0809135419339359PMC3894622 | β | β | β |
| CoanJAAllenJJFrontal EEG asymmetry as a moderator and mediator of emotion.Biol Psychol20046774910.1016/j.biopsycho.2004.03.00215130524 | β | β | β |
| CoanJAAllenJJMcKnightPEA capability model of individual differences in frontal EEG asymmetry.Biol Psychol2006721982071631671710.1016/j.biopsycho.2005.10.003PMC2835626 | β | β | β |
| DavidsonRJAnterior cerebral asymmetry and the nature of emotion.Brain Cogn19922012515110.1016/0278-2626(92)90065-T1389117 | β | β | β |
| De GeusEJBoomsmaDIA genetic neuroscience approach to human cognition.Eur Psychol2001624125310.1027//1016-9040.6.4.241 | β | β | β |
| de GeusEJIntroducing genetic psychophysiology.Biol Psychol20026111010.1016/S0301-0511(02)00049-212385666 | β | β | β |
| EysenckHJEysenckMWPersonality and Individual Differences1985New York: Plenum | β | β | β |
| GottesmanIIGouldTDThe endophenotype concept in psychiatry: etymology and strategic intentions.Am J Psychiatry200316063664510.1176/appi.ajp.160.4.63612668349 | β | β | β |
| GottesmanIISchizophrenia Genesis1991New York: WH Freeman | β | β | β |
| GrayJAThe Neuropsychology of Anxiety1982Oxford: Clarendon | β | β | β |
| HallMHSchulzeKRijsdijkFKalidindiSMcDonaldCBramonEMurrayRMShamPAre auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Study.Psychol Med2009391277128710.1017/S003329170900526119250581 | β | β | β |
| Harmon-JonesEGablePAPetersonCKThe role of asymmetric frontal cortical activity in emotion-related phenomena: A review and update.Biol Psychol20091973361810.1016/j.biopsycho.2009.08.010 | β | β | β |
| HettemaJMNealeMCKendlerKSA review and meta-analysis of the genetic epidemiology of anxiety disorders.Am J Psychiatry20011581568157810.1176/appi.ajp.158.10.156811578982 | β | β | β |
| JormAFChristensenHGriffithsKMPublic beliefs about causes and risk factors for mental disorders: changes in Australia over 8 years.Soc Psychiatry Psychiatr Epidemiol20054076476710.1007/s00127-005-0940-z16133745 | β | β | β |
| Linkenkaer-HansenKSmitDJBarkilAvan BeijsterveldtTEBrussaardABBoomsmaDIvan OoyenAde GeusEJGenetic contributions to long-range temporal correlations in ongoing oscillations.J Neurosci200727138821388910.1523/JNEUROSCI.3083-07.200718077700PMC6673639 | β | β | β |
| LottaLAGenome-wide association studies in atherothrombosis.Eur J Intern Med201021747810.1016/j.ejim.2009.11.00320206874 | β | β | β |
| McCarthyMIZegginiEGenome-wide association studies in type 2 diabetes.Curr Diab Rep200991641711932396210.1007/s11892-009-0027-4PMC2694564 | β | β | β |
| MillerGHoldenCPsychiatry. Proposed revisions to psychiatry's canon unveiled.Science201032777077110.1126/science.327.5967.770-a20150459 | β | β | β |
| MoskvinaVCraddockNHolmansPNikolovIPahwaJSGreenEOwenMJO'DonovanMCGene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.Mol Psychiatry20091425226010.1038/mp.2008.13319065143PMC3970088 | β | β | β |
| NieuwenhuisSAston-JonesGCohenJDDecision making, the P3, and the locus coeruleus-norepinephrine system.Psychol Bull200513151053210.1037/0033-2909.131.4.51016060800 | β | β | β |
| NieuwenhuisSde GeusEJAston-JonesGThe anatomical and functional relationship between the P3 and autonomic components of the orienting response.Psychophysiology20102055748010.1111/j.1469-8986.2010.01057.xPMC3797154 | β | β | β |
| OwenMJWilliamsHJO'DonovanMCSchizophrenia genetics: advancing on two fronts.Curr Opin Genet Dev20091926627010.1016/j.gde.2009.02.00819345090 | β | β | β |
| PerlmanGJohnsonWIaconoWGThe heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use.Psychophysiology2009469629691955840210.1111/j.1469-8986.2009.00850.xPMC2892841 | β | β | β |
| PosthumaDMulderEJBoomsmaDIde GeusEJGenetic analysis of IQ, processing speed and stimulus-response incongruency effects.Biol Psychol20026115718210.1016/S0301-0511(02)00057-112385674 | β | β | β |
| PosthumaDNealeMCBoomsmaDIde GeusEJAre smarter brains running faster? Heritability of alpha peak frequency, IQ, and their interrelation.Behav Genet20013156757910.1023/A:101334541177411838534 | β | β | β |
| RheeSHHewittJKYoungSECorleyRPCrowleyTJStallingsMCGenetic and environmental influences on substance initiation, use, and problem use in adolescents.Arch Gen Psychiatry2003601256126410.1001/archpsyc.60.12.125614662558 | β | β | β |
| RietveldMJHudziakJJBartelsMVan BeijsterveldtCEBoomsmaDIHeritability of attention problems in children: longitudinal results from a study of twins, age 3 to 12.J Child Psychol Psychiatry20044557758810.1111/j.1469-7610.2004.00247.x15055376 | β | β | β |
| RutterMGenetic studies of autism: from the 1970 s into the millennium.J Abnorm Child Psychol20002831410.1023/A:100511390006810772346 | β | β | β |
| SmitCMWrightMJHansellNKGeffenGMMartinNGGenetic variation of individual alpha frequency (IAF) and alpha power in a large adolescent twin sample.Int J Psychophysiol20066123524310.1016/j.ijpsycho.2005.10.00416338015 | β | β | β |
| SmitDJBoersmaMVan BeijsterveldtCEPosthumaDBoomsmaDIStamCJde GeusEJEndophenotypes in a dynamically connected brain.Behav Genet2010401671772011199310.1007/s10519-009-9330-8PMC2829652 | β | β | β |
| SmitDJPosthumaDBoomsmaDIde GeusEJGenetic contribution to the P3 in young and middle-aged adults.Twin Res Hum Genet20071033534710.1375/twin.10.2.33517564523 | β | β | β |
| SmitDJPosthumaDBoomsmaDIde GeusEJHeritability of anterior and posterior visual N1.Int J Psychophysiol20076619620410.1016/j.ijpsycho.2007.06.00517669532 | β | β | β |
| SmitDJPosthumaDBoomsmaDIde GeusEJThe relation between frontal EEG asymmetry and the risk for anxiety and depression.Biol Psychol200774263310.1016/j.biopsycho.2006.06.00216875773 | β | β | β |
| SmitDJPosthumaDBoomsmaDIGeusEJHeritability of background EEG across the power spectrum.Psychophysiology20054269169710.1111/j.1469-8986.2005.00352.x16364064 | β | β | β |
| SullivanPFNealeMCKendlerKSGenetic epidemiology of major depression: Review and meta-analysis.Am J Psychiatry20001571552156210.1176/appi.ajp.157.10.155211007705 | β | β | β |
| TuretskyBICalkinsMELightGAOlincyARadantADSwerdlowNRNeurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures.Schizophr Bull20073369941713548210.1093/schbul/sbl060PMC2632291 | β | β | β |
| Van't EntDVan SoelenILStamCJde GeusEJBoomsmaDIStrong resemblance in the amplitude of oscillatory brain activity in monozygotic twins is not caused by "trivial" similarities in the composition of the skull.Hum Brain Mapp2009302142214510.1002/hbm.2065618819108PMC6871129 | β | β | β |
| Van't EntDVan SoelenILStamKJde GeusEJBoomsmaDIGenetic influence demonstrated for MEG-recorded somatosensory evoked responses.Psychophysiology20102040901710.1111/j.1469-8986.2010.01012.x | β | β | β |
| WeissLAArkingDEDalyMJChakravartiAA genome-wide linkage and association scan reveals novel loci for autism.Nature20094618028081981267310.1038/nature08490PMC2772655 | β | β | β |
| WrightMJHansellNKGeffenGMGeffenLBSmithGAMartinNGGenetic influence on the variance in P3 amplitude and latency.Behav Genet20013155556510.1023/A:101339332770411838533 | β | β | β |
| ZietschBPHansenJLHansellNKGeffenGMMartinNGWrightMJCommon and specific genetic influences on EEG power bands delta, theta, alpha, and beta.Biol Psychol20077515416410.1016/j.biopsycho.2007.01.00417316957 | β | β | β |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| [Electroencephalography: features of the obtained data and its applicability in psychiatry]. | Chizhikova AA | β | 2024 | β |
| A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment. | Bel-Bahar TS et al. | β | 2022 | β |
| Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. | Smit DJA et al. | β | 2021 | β |
| Resting-state EEG theta activity reflects degree of genetic determination of the major epilepsy syndromes. | Clemens B et al. | β | 2021 | β |
| Risk Variants in Three Alzheimer's Disease Genes Show Association with EEG Endophenotypes. | Macedo A et al. | β | 2021 | β |
| Genome-Wide Scan for Five Brain Oscillatory Phenotypes Identifies a New QTL Associated with Theta EEG Band. | Rebelo MΓ et al. | β | 2020 | β |
| The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine. | Yang Z et al. | β | 2020 | β |
| EEG-based age-prediction models as stable and heritable indicators of brain maturational level in children and adolescents. | Vandenbosch MMLJZ et al. | β | 2019 | β |
| Theta resting EEG in the right TPJ is associated with individual differences in implicit intergroup bias. | Schiller B et al. | β | 2019 | β |
| Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. | Smit DJA et al. | β | 2018 | β |
| Neural processing of working memory in adults with ADHD in a visuospatial change detection task with distractors. | Gu C et al. | β | 2018 | β |
| Can neurophysiologic measures serve as biomarkers for the efficacy of repetitive transcranial magnetic stimulation treatment of major depressive disorder? | Kobayashi B et al. | β | 2017 | β |
| What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude? | Malone SM et al. | β | 2017 | β |
| Genetic effects on source level evoked and induced oscillatory brain responses in a visual oddball task. | Antonakakis M et al. | β | 2016 | β |
| Research Review: Use of EEG biomarkers in child psychiatry research - current state and future directions. | Loo SK et al. | β | 2016 | β |
| Genetics and brain morphology. | Strike LT et al. | β | 2015 | β |
| Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology. | Yoon HH et al. | β | 2015 | β |
| A neural trait approach to exploring individual differences in social preferences. | Nash K et al. | β | 2014 | β |
| Genetic psychophysiology: advances, problems, and future directions. | Anokhin AP | β | 2014 | β |
| Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study. | Vaidyanathan U et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Intermediate phenotypes and biomarkers of treatment outcome in major depressive disorder. | Leuchter AF et al. | β | 2014 | β |
| Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries. | Iacono WG et al. | β | 2014 | β |
| Molecular genetic psychophysiology: a perspective on the Minnesota contribution. | de Geus EJ | β | 2014 | β |
| The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. | Thompson PM et al. | β | 2014 | β |
| Autism as early neurodevelopmental disorder: evidence for an sAPPΞ±-mediated anabolic pathway. | Lahiri DK et al. | β | 2013 | β |
| Endophenotypes in psychopathology research: where do we stand? | Miller GA et al. | β | 2013 | β |
| Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging. | Kremen WS et al. | β | 2013 | β |
| Long-range temporal correlations in resting-state Ξ± oscillations predict human timing-error dynamics. | Smit DJ et al. | β | 2013 | β |
| Pre-attentive information processing and impulsivity in bipolar disorder. | Swann AC et al. | β | 2013 | β |
| Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins. | Hibar DP et al. | β | 2012 | β |
| Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. | Vrieze SI et al. | β | 2012 | β |
| EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes. | Clemens B et al. | β | 2012 | β |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | β | 2012 | β |
| Family-based genome-wide association study of frontal ΞΈ oscillations identifies potassium channel gene KCNJ6. | Kang SJ et al. | β | 2012 | β |
| Measuring the maturity of the fast-spiking interneuron transcriptional program in autism, schizophrenia, and bipolar disorder. | Gandal MJ et al. | β | 2012 | β |
| Neuroimaging and genetics: exploring, searching, and finding. | Smit DJ et al. | β | 2012 | β |
| Relating human genetic variation to variation in drug responses. | Madian AG et al. | β | 2012 | β |
| Why Some People Discount More than Others: Baseline Activation in the Dorsal PFC Mediates the Link between COMT Genotype and Impatient Choice. | Gianotti LR et al. | β | 2012 | β |
| Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder. | Tye C et al. | β | 2011 | β |