Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells.
paper
Cited
Public
- Authors
- Prytkova, Iya; Brennand, Kristen J
- Year
- 2017
- Journal
- Frontiers in cellular neuroscience
- PMID
- 29217999
- DOI
- 10.3389/fncel.2017.00360
- PMCID
- PMC5703699
Excitatory dopaminergic neurons, inhibitory GABAergic neurons, microglia, and oligodendrocytes have all been implicated in schizophrenia (SZ) network pathology. Still, SZ has been a difficult disorder to study, not only because of the limitations of animal models in capturing the complexity of the human mind, but also because it is greatly polygenic, with high rates of variability across the population. The advent of patient-derived pluripotent stem cells and induced neural and glial cultures has brought hope for modeling the molecular dysfunction underlying SZ pathology in a patient-specific manner. Here I review the successes of the patient-specific induced cultures in generating different cell types for the study of SZ, with special emphasis on the utility of co-culture techniques, both two- and three-dimensional, for modeling network dysfunction in disease.
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| 20 | Patient hiPscs-Derived Brain Cells for Modeling Schizophrenia β Modeling Regional Specificity and Circuitry | While there is solid evidence that the neuropathologies of SZ often precede symptom onset, there areβ¦ |
| 21 | Concluding Remarks | Despite being in a nascent stage of methodological development, hiPSC-derived neurons show promise⦠|
| 22 | Concluding Remarks | Of course, many limitations accompany the use of tissue culture to model psychiatric disease. Aside⦠|
| 23 | Concluding Remarks | Given the developmental underpinnings and genetic heterogeneity of SZ, hiPSC cultures should⦠|
| 24 | Author Contributions | IP gathered references and wrote the manuscript. KB revised the manuscript and provided additional⦠|
| 25 | Conflict of Interest Statement | The authors declare that the research was conducted in the absence of any commercial or financial⦠|
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