Pharmacogenomics and personalized medicine in neuropsychiatry.
paper
Cited
Public
- Authors
- McMahon, Francis J; Insel, Thomas R
- Year
- 2012
- Journal
- Neuron
- PMID
- 22681682
- DOI
- 10.1016/j.neuron.2012.05.004
- PMCID
- PMC3407812
Despite the need for more effective treatments for psychiatric disorders, development of new medications has stalled. Here we discuss the promise of personalized medicine in developing more efficacious and individualized pharmacotherapies that take into account genetic variation and target groups of patients who share biology, not just symptoms.
The nested relationship between personalized medicine, genomic medicine, and pharmacogenetics and genomics.
Approaches to the pharmacogenomics of psychotropic medications. Individual variation reflects both genetic and non-genetic factors that converge on the absorption, distribution, central target, metabolism, and toxicity of medications.
| # | Section | Preview |
|---|---|---|
| 20 | Conclusion: Some paths forward — Pharmacogenomics for identifying new drug targets | Traditional drug development pipelines are inefficient and expensive. Innovative strategies are… |
| 21 | Conclusion: Some paths forward — Pharmacogenomics for identifying new drug targets | Large-scale sequencing of the genome is providing another new perspective. Thanks to this new… |
| 22 | Conclusion: Some paths forward — Pharmacogenomics for identifying new drug targets | Genetics is not the whole answer, but offers a solid starting point. Further knowledge of the basic… |
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| Title | Year | PMID |
|---|---|---|
| Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation. | 2015 | 26142345 |
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