Quantitative genetic modeling of variation in human brain morphology.
paper
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- Authors
- BaarΓ©, W F; Hulshoff Pol, H E; Boomsma, D I; Posthuma, D; de Geus, E J; Schnack, H G; van Haren, N E; van Oel, C J; Kahn, R S
- Year
- 2001
- Journal
- Cerebral cortex (New York, N.Y. : 1991)
- PMID
- 11532887
- DOI
- 10.1093/cercor/11.9.816
The degree to which individual variation in brain structure in humans is genetically or environmentally determined is as yet not well understood. We studied the brains of 54 monozygotic (33 male, 21 female) and 58 dizygotic (17 male, 20 female, 21 opposite sex) pairs of twins and 34 of their full siblings (19 male, 15 female) by means of high resolution magnetic resonance imaging scans. Structural equation modeling was used to quantify the genetic and environmental contributions to phenotypic (co)variance in whole brain, gray and white matter volume of the cerebrum, lateral ventricle volume and associated variables such as intracranial volume and height. Because the cerebral cortex makes up more that two-thirds of the brain mass and almost three-quarters of its synapses, our data predominantly concerns the telencephalon. Genetic factors accounted for most of the individual differences in whole brain (90%), gray (82%) and white (88%) matter volume. Individual differences in lateral ventricle volume were best explained by a model containing common (58%) and unique (42%) environmental factors, indicating genes to be of no or minor influence. In our sample, genetic or environmental influences were not different for males and females. The same genes influenced brain volumes and intracranial volume and almost completely explained their high phenotypic correlation. Genes influencing gray and white matter overlapped to a large extent and completely determined their phenotypic correlation. The high heritability estimates that were found indicate that brain volumes may be useful as intermediate phenotypes in behavioral genetic research.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study. | Labounek R et al. | β | 2025 | β |
| Morphological Brain Alterations and Network Disorganizations in Individuals With Substance Use Disorders: Differential Effects of Heroin Versus Methamphetamine. | Zhou X et al. | β | 2025 | β |
| Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children. | Joo YY et al. | β | 2025 | β |
| Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque. | Ahmed B et al. | β | 2024 | β |
| Gray and White Matter Metrics Demonstrate Distinct and Complementary Prediction of Differences in Cognitive Performance in Children: Findings from ABCD (<i>N</i>β=β11,876). | Michel LC et al. | β | 2024 | β |
| Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children | Joo YY et al. | β | 2024 | β |
| Increasing diversity in connectomics with the Chinese Human Connectome Project. | Ge J et al. | β | 2023 | β |
| Structural neuroimaging phenotypes and associated molecular and genomic underpinnings in autism: a review. | Pretzsch CM et al. | β | 2023 | β |
| The multimodal Munich Clinical Deep Phenotyping study to bridge the translational gap in severe mental illness treatment research. | KrΔmΓ‘Ε L et al. | β | 2023 | β |
| Greater male than female variability in regional brain structure across the lifespan. | Wierenga LM et al. | β | 2022 | β |
| Heritability of Subcortical Grey Matter Structures. | Strelnikov D et al. | β | 2022 | β |
| Imaging Transcriptomics of Brain Disorders. | Arnatkeviciute A et al. | β | 2022 | β |
| Microcephaly measurement in adults and its association with clinical variables. | Costa NRD et al. | β | 2022 | β |
| The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years. | Gillespie NA et al. | β | 2022 | β |
| Human Connectome Project: heritability of brain volumes in young healthy adults. | Christova P et al. | β | 2021 | β |
| The Heritability of Cortical Folding: Evidence from the Human Connectome Project. | Schmitt JE et al. | β | 2021 | β |
| Where the genome meets the connectome: Understanding how genes shape human brain connectivity. | Arnatkeviciute A et al. | β | 2021 | β |
| Genetic and Environmental Influences on Lobar Brain Structures in Twins With Autism. | Hegarty JP et al. | β | 2020 | β |
| Genetic and environmental influences on structural brain measures in twins with autism spectrum disorder. | Hegarty JP et al. | β | 2020 | β |
| Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. | Mathias SR et al. | β | 2020 | β |
| Twin MRI studies on genetic and environmental determinants of brain morphology and function in the early lifespan. | Maggioni E et al. | β | 2020 | β |
| A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. | van der Lee SJ et al. | β | 2019 | β |
| Human Cortical Thickness Organized into Genetically-determined Communities across Spatial Resolutions. | Alexander-Bloch AF et al. | β | 2019 | β |
| Joint representation of connectome-scale structural and functional profiles for identification of consistent cortical landmarks in macaque brain. | Zhang S et al. | β | 2019 | β |
| The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. | Ligthart L et al. | β | 2019 | β |
| A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia. | Sakamoto K et al. | β | 2018 | β |
| A Key Characteristic of Sex Differences in the Developing Brain: Greater Variability in Brain Structure of Boys than Girls. | Wierenga LM et al. | β | 2018 | β |
| A subject-transfer framework for obviating inter- and intra-subject variability in EEG-based drowsiness detection. | Wei CS et al. | β | 2018 | β |
| Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia. | Lin D et al. | β | 2018 | β |
| Does risk of brain cancer increase with intracranial volume? A population-based case control study. | Fyllingen EH et al. | β | 2018 | β |
| Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategies. | Patel S et al. | β | 2018 | β |
| Structural Variability Across the Primate Brain: A Cross-Species Comparison. | Croxson PL et al. | β | 2018 | β |
| A seed-based cross-modal comparison of brain connectivity measures. | Reid AT et al. | β | 2017 | β |
| Associations between subjective well-being and subcortical brain volumes. | Van 't Ent D et al. | β | 2017 | β |
| Developmental trajectories of macroanatomical structures in common marmoset brain. | Seki F et al. | β | 2017 | β |
| Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. | Brouwer RM et al. | β | 2017 | β |
| Genetic variation within GRIN2B in adolescents with alcohol use disorder may be associated with larger left posterior cingulate cortex volume. | Dalvie S et al. | β | 2017 | β |
| Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults. | Lukies MW et al. | β | 2017 | β |
| Heritability of hippocampal subfield volumes using a twin and non-twin siblings design. | Patel S et al. | β | 2017 | β |
| Island Rule, quantitative genetics and brain-body size evolution in <i>Homo floresiensis</i>. | Diniz-Filho JAF et al. | β | 2017 | β |
| Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker. | Cole JH et al. | β | 2017 | β |
| Radial Structure Scaffolds Convolution Patterns of Developing Cerebral Cortex. | Razavi MJ et al. | β | 2017 | β |
| The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder<sup>1</sup>. | Mallas E et al. | β | 2017 | β |
| Twins methods quantitatively explore the genetic impact on children and adolescents brain gray matter volume. | Chen XL et al. | β | 2017 | β |
| A cross-modal, cross-species comparison of connectivity measures in the primate brain. | Reid AT et al. | β | 2016 | β |
| Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism and Risk of Schizophrenia: A Meta-analysis of Case-Control Studies. | Kheirollahi M et al. | β | 2016 | β |
| Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure. | Bohlken MM et al. | β | 2016 | β |
| The association between hippocampal volume and life events in healthy twins. | Bootsman F et al. | β | 2016 | β |
| Topology of genetic associations between regional gray matter volume and intellectual ability: Evidence for a high capacity network. | Bohlken MM et al. | β | 2016 | β |
| Toward an integrative science of the developing human mind and brain: Focus on the developing cortex. | Jernigan TL et al. | β | 2016 | β |
| A framework for analyzing the relationship between gene expression and morphological, topological, and dynamical patterns in neuronal networks. | de Arruda HF et al. | β | 2015 | β |
| Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder. | Bootsman F et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use. | Prom-Wormley E et al. | β | 2015 | β |
| Genetic and environmental influences on cortical surface area and cortical thickness in bipolar disorder. | Bootsman F et al. | β | 2015 | β |
| Genetics and brain morphology. | Strike LT et al. | β | 2015 | β |
| Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia. | Voineskos AN | β | 2015 | β |
| Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia. | Roalf DR et al. | β | 2015 | β |
| Intra-Individual Consistency in Endocrine Profiles Across Successive Pregnancies. | Fox M et al. | β | 2015 | β |
| Quantitative genetic analysis of brain size variation in sticklebacks: support for the mosaic model of brain evolution. | Noreikiene K et al. | β | 2015 | β |
| What twin studies tell us about the heritability of brain development, morphology, and function: a review. | Jansen AG et al. | β | 2015 | β |
| A three-way parallel ICA approach to analyze links among genetics, brain structure and brain function. | Vergara VM et al. | β | 2014 | β |
| Automated whole-brain N-acetylaspartate proton MRS quantification. | Soher BJ et al. | β | 2014 | β |
| Automatic clustering and population analysis of white matter tracts using maximum density paths. | Prasad G et al. | β | 2014 | β |
| Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions. | Woldehawariat G et al. | β | 2014 | β |
| Genes contributing to subcortical volumes and intellectual ability implicate the thalamus. | Bohlken MM et al. | β | 2014 | β |
| Genes, evolution and intelligence. | Bouchard TJ | β | 2014 | β |
| Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood. | Douet V et al. | β | 2014 | β |
| Heritability of brain volumes in older adults: the Older Australian Twins Study. | Batouli SA et al. | β | 2014 | β |
| Heritability of structural brain network topology: a DTI study of 156 twins. | Bohlken MM et al. | β | 2014 | β |
| Sparse models for correlative and integrative analysis of imaging and genetic data. | Lin D et al. | β | 2014 | β |
| The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse. | Dalvie S et al. | β | 2014 | β |
| The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. | Thompson PM et al. | β | 2014 | β |
| The heritability of volumes of brain structures and its relationship to age: a review of twin and family studies. | Batouli SA et al. | β | 2014 | β |
| The neuropsychological contributors to psychopathic personality traits in adolescence. | May JS et al. | β | 2014 | β |
| What contributes to individual differences in brain structure? | Gu J et al. | β | 2014 | β |
| Abnormal subcortical components of the corticostriatal system in young adults with DLI: a combined structural MRI and DTI study. | Lee JC et al. | β | 2013 | β |
| Analytical strategies for large imaging genetic datasets: experiences from the IMAGEN study. | Nymberg C et al. | β | 2013 | β |
| Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes. | Liu ME et al. | β | 2013 | β |
| Genes encoding heterotrimeric G-proteins are associated with gray matter volume variations in the medial frontal cortex. | ChavarrΓa-Siles I et al. | β | 2013 | β |
| Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. | Terwisscha van Scheltinga AF et al. | β | 2013 | β |
| Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging. | Kremen WS et al. | β | 2013 | β |
| Heritability of subcortical brain measures: a perspective for future genome-wide association studies. | den Braber A et al. | β | 2013 | β |
| Heritability of volumetric brain changes and height in children entering puberty. | van Soelen IL et al. | β | 2013 | β |
| Imaging structural co-variance between human brain regions. | Alexander-Bloch A et al. | β | 2013 | β |
| Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM). | Sandiego CM et al. | β | 2013 | β |
| Structural networks in Alzheimer's disease. | Reid AT et al. | β | 2013 | β |
| The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. | Willemsen G et al. | β | 2013 | β |
| [Are variations of structural neuro-anatomy promising endophenotype candidates in bipolar disorder?]. | Mazzola-Pomietto P et al. | β | 2012 | β |
| Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. | Bakken TE et al. | β | 2012 | β |
| Association study of copy number variants with brain volume in schizophrenia patients and healthy controls. | Terwisscha van Scheltinga A et al. | β | 2012 | β |
| Correlation among body height, intelligence, and brain gray matter volume in healthy children. | Taki Y et al. | β | 2012 | β |
| Genetic and environmental influences on cortical thickness among 14-year-old twins. | Yang Y et al. | β | 2012 | β |
| Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies. | Blokland GA et al. | β | 2012 | β |
| Genetic architecture of declarative memory: implications for complex illnesses. | Bearden CE et al. | β | 2012 | β |
| Genetic influences on thinning of the cerebral cortex during development. | van Soelen IL et al. | β | 2012 | β |
| Genome-wide linkage analysis of human auditory cortical activation suggests distinct loci on chromosomes 2, 3, and 8. | Renvall H et al. | β | 2012 | β |
| Heritability of brain ventricle volume: converging evidence from inconsistent results. | Kremen WS et al. | β | 2012 | β |
| Individual differences in EEG spectral power reflect genetic variance in gray and white matter volumes. | Smit DJ et al. | β | 2012 | β |
| Longitudinal development of cortical and subcortical gray matter from birth to 2 years. | Gilmore JH et al. | β | 2012 | β |
| Longitudinal genetic analysis of brain volumes in normal elderly male twins. | Lessov-Schlaggar CN et al. | β | 2012 | β |
| Mapping genetic and environmental influences on cortical surface area of pediatric twins. | Yoon U et al. | β | 2012 | β |
| Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia. | Owens SF et al. | β | 2012 | β |
| The brain matures with stronger functional connectivity and decreased randomness of its network. | Smit DJ et al. | β | 2012 | β |
| The corpus callosum in monozygotic twins concordant and discordant for handedness and language dominance. | HΓ€berling IS et al. | β | 2012 | β |
| The TWIN-E project in emotional wellbeing: study protocol and preliminary heritability results across four MRI and DTI measures. | Gatt JM et al. | β | 2012 | β |
| TwinMARM: two-stage multiscale adaptive regression methods for twin neuroimaging data. | Li Y et al. | β | 2012 | β |
| Anatomy of human sensory cortices reflects inter-individual variability in time estimation. | Gilaie-Dotan S et al. | β | 2011 | β |
| Annual Research Review: Developmental considerations of gene by environment interactions. | Lenroot RK et al. | β | 2011 | β |
| Brain structure in young and old East Asians and Westerners: comparisons of structural volume and cortical thickness. | Chee MW et al. | β | 2011 | β |
| COMT gene polymorphism and corpus callosum morphometry in preterm born adults. | Dutt A et al. | β | 2011 | β |
| Genetic and environmental influences on structural variability of the brain in pediatric twin: deformation based morphometry. | Yoon U et al. | β | 2011 | β |
| Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness. | Karlsgodt KH et al. | β | 2011 | β |
| Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study. | Eyler LT et al. | β | 2011 | β |
| Heritability of verbal and performance intelligence in a pediatric longitudinal sample. | van Soelen IL et al. | β | 2011 | β |
| Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. | Tate DF et al. | β | 2011 | β |
| Morphological variability of the subcallosal area of man. | SpasojeviΔ GD et al. | β | 2011 | β |
| Postnatal brain development: structural imaging of dynamic neurodevelopmental processes. | Jernigan TL et al. | β | 2011 | β |
| Twin-singleton differences in neonatal brain structure. | Knickmeyer RC et al. | β | 2011 | β |
| A multimodal assessment of the genetic control over working memory. | Karlsgodt KH et al. | β | 2010 | β |
| Anatomic magnetic resonance imaging of the developing child and adolescent brain and effects of genetic variation. | Giedd JN et al. | β | 2010 | β |
| Are there differences in brain morphometry between twins and unrelated singletons? A pediatric MRI study. | Ordaz SJ et al. | β | 2010 | β |
| [Asymmetry and sexual dimorphism of the medial frontal gyrus visible surface in humans]. | SpasojeviΔ G et al. | β | 2010 | β |
| A twin study of intracerebral volumetric relationships. | Schmitt JE et al. | β | 2010 | β |
| Brain plasticity and intellectual ability are influenced by shared genes. | Brans RG et al. | β | 2010 | β |
| Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. | Winkler AM et al. | β | 2010 | β |
| [Digital morphometric study of the extrasulcal surface of the cingulate gyrus in man]. | SpasojeviΔ G et al. | β | 2010 | β |
| Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia. | Koolschijn PC et al. | β | 2010 | β |
| Genetic and environmental contributions to neonatal brain structure: A twin study. | Gilmore JH et al. | β | 2010 | β |
| Genetic and environmental influences on focal brain density in bipolar disorder. | van der Schot AC et al. | β | 2010 | β |
| Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study. | Kremen WS et al. | β | 2010 | β |
| Genetic covariation between brain volumes and IQ, reading performance, and processing speed. | Betjemann RS et al. | β | 2010 | β |
| Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary. | Ivleva EI et al. | β | 2010 | β |
| Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia. | Bertisch H et al. | β | 2010 | β |
| Heritability of head size in Dutch and Australian twin families at ages 0-50 years. | Smit DJ et al. | β | 2010 | β |
| Lateralized genetic and environmental influences on human brain morphology of 8-year-old twins. | Yoon U et al. | β | 2010 | β |
| Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. | Eastwood SL et al. | β | 2010 | β |
| Measuring selection in contemporary human populations. | Stearns SC et al. | β | 2010 | β |
| Progressive lateral ventricular enlargement in schizophrenia: a meta-analysis of longitudinal MRI studies. | Kempton MJ et al. | β | 2010 | β |
| Bivariate heritability of total and regional brain volumes: the Framingham Study. | DeStefano AL et al. | β | 2009 | β |
| Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence. | Lenroot RK et al. | β | 2009 | β |
| Does having a twin brother make for a bigger brain? | Peper JS et al. | β | 2009 | β |
| DTNBP1 is associated with imaging phenotypes in schizophrenia. | Narr KL et al. | β | 2009 | β |
| Endophenotypes in normal brain morphology and Alzheimer's disease: a review. | Reitz C et al. | β | 2009 | β |
| Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs. | Peper JS et al. | β | 2009 | β |
| Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia. | Kaymaz N et al. | β | 2009 | β |
| Mapping genetic influences on ventricular structure in twins. | Chou YY et al. | β | 2009 | β |
| Mapping growth patterns and genetic influences on early brain development in twins. | Chen Y et al. | β | 2009 | β |
| Mapping the regional influence of genetics on brain structure variability--a tensor-based morphometry study. | Brun CC et al. | β | 2009 | β |
| The genetic control of neocortex volume and covariation with neocortical gene expression in mice. | Gaglani SM et al. | β | 2009 | β |
| Brain development: anatomy, connectivity, adaptive plasticity, and toxicity. | Kalia M | β | 2008 | β |
| Brain neuroplasticity in healthy, hyperactive and psychotic children: insights from neuroimaging. | Rapoport JL et al. | β | 2008 | β |
| Genes and structural brain imaging in schizophrenia. | van Haren NE et al. | β | 2008 | β |
| Hypothalamus volume in twin pairs discordant for schizophrenia. | Koolschijn PC et al. | β | 2008 | β |
| Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. | Schmitt JE et al. | β | 2008 | β |
| Imaging the genetics of brain structure and function. | de Geus E et al. | β | 2008 | β |
| Multigenic factors associated with a hydrocephalus-like phenotype found in inter-subspecific consomic mouse strains. | Takahashi A et al. | β | 2008 | β |
| Neural phenotypes of common and rare genetic variants. | Bearden CE et al. | β | 2008 | β |
| Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T. | Gonen O et al. | β | 2008 | β |
| Regional metabolite T2 in the healthy rhesus macaque brain at 7T. | Liu S et al. | β | 2008 | β |
| Schizophrenia as a progressive brain disease. | van Haren NE et al. | β | 2008 | β |
| Sex-linked neuroanatomical basis of human altruistic cooperativeness. | Yamasue H et al. | β | 2008 | β |
| Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"? | Prasad KM et al. | β | 2008 | β |
| The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined. | Pinborg LH et al. | β | 2008 | β |
| The changing impact of genes and environment on brain development during childhood and adolescence: initial findings from a neuroimaging study of pediatric twins. | Lenroot RK et al. | β | 2008 | β |
| Trajectories of anatomic brain development as a phenotype. | Giedd JN et al. | β | 2008 | β |
| A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sample. | Schmitt JE et al. | β | 2007 | β |
| Are brain structural abnormalities useful as endophenotypes in schizophrenia? | Keshavan MS et al. | β | 2007 | β |
| Cortical mapping of genotype-phenotype relationships in schizophrenia. | Bearden CE et al. | β | 2007 | β |
| Genetic influences on human brain structure: a review of brain imaging studies in twins. | Peper JS et al. | β | 2007 | β |
| Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. | Benegal V et al. | β | 2007 | β |
| Heritability of bipolar EEG spectra in a large sib-pair population. | Tang Y et al. | β | 2007 | β |
| Heritability of brain volume, surface area and shape: an MRI study in an extended pedigree of baboons. | Rogers J et al. | β | 2007 | β |
| Investigation of MCPH1 G37995C and ASPM A44871G polymorphisms and brain size in a healthy cohort. | Dobson-Stone C et al. | β | 2007 | β |
| Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function. | Glahn DC et al. | β | 2007 | β |
| Parental alcohol use and brain volumes in early- and late-onset alcoholics. | Gilman JM et al. | β | 2007 | β |
| Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. | Rujescu D et al. | β | 2007 | β |
| Relationships between IQ and regional cortical gray matter thickness in healthy adults. | Narr KL et al. | β | 2007 | β |
| Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment. | Schmitt JE et al. | β | 2007 | β |
| Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age. | Sowell ER et al. | β | 2007 | β |
| The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence. | Mekel-Bobrov N et al. | β | 2007 | β |
| Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods. | O'Brien LM et al. | β | 2006 | β |
| A pediatric twin study of brain morphometry. | Wallace GL et al. | β | 2006 | β |
| Birth characteristics and risk of low intellectual performance in early adulthood: are the associations confounded by socioeconomic factors in adolescence or familial effects? | Bergvall N et al. | β | 2006 | β |
| Endophenotypes for psychiatric disorders: ready for primetime? | Bearden CE et al. | β | 2006 | β |
| Genetic contributions to human brain morphology and intelligence. | Hulshoff Pol HE et al. | β | 2006 | β |
| Genetics of intelligence. | Deary IJ et al. | β | 2006 | β |
| Genomic regulation of natural variation in cortical and noncortical brain volume. | Beatty J et al. | β | 2006 | β |
| Intelligence and brain size in 100 postmortem brains: sex, lateralization and age factors. | Witelson SF et al. | β | 2006 | β |
| Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophrenia. | Cannon TD et al. | β | 2006 | β |
| Netherlands Twin Register: from twins to twin families. | Boomsma DI et al. | β | 2006 | β |
| Role of mechanical factors in the morphology of the primate cerebral cortex. | Hilgetag CC et al. | β | 2006 | β |
| The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. | Ohnishi T et al. | β | 2006 | β |
| Use of magnetic resonance imaging in tracking the course and treatment of schizophrenia. | Kumari V et al. | β | 2006 | β |
| An evolutionary theory of human motivation. | Bernard LC et al. | β | 2005 | β |
| Consequences of large interindividual variability for human brain atlases: converging macroscopical imaging and microscopical neuroanatomy. | Uylings HB et al. | β | 2005 | β |
| Developmental mechanics of the primate cerebral cortex. | Hilgetag CC et al. | β | 2005 | β |
| Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls. | Durston S et al. | β | 2005 | β |
| Genetics of brain structure and intelligence. | Toga AW et al. | β | 2005 | β |
| Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA study. | Turner ST et al. | β | 2005 | β |
| Neurobiology of emotion and high risk for schizophrenia: role of the amygdala and the X-chromosome. | van Rijn S et al. | β | 2005 | β |
| Neuroimaging and human genetics. | Winterer G et al. | β | 2005 | β |
| The phenotypes of bipolar disorder: relevance for genetic investigations. | MacQueen GM et al. | β | 2005 | β |
| A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia. | van Haren NE et al. | β | 2004 | β |
| Cerebral volume loss, cognitive deficit and neuropsychological performance: comparative measures of brain atrophy: I. Dementia. | Bigler ED et al. | β | 2004 | β |
| Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia. | Hulshoff Pol HE et al. | β | 2004 | β |
| Heterozygous PAX6 mutation, adult brain structure and fronto-striato-thalamic function in a human family. | Ellison-Wright Z et al. | β | 2004 | β |
| Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism. | Kates WR et al. | β | 2004 | β |
| Neurobiology of intelligence: science and ethics. | Gray JR et al. | β | 2004 | β |
| Why genetic investigation of psychiatric disorders is so difficult. | Bearden CE et al. | β | 2004 | β |
| Genetics of human prefrontal function. | Winterer G et al. | β | 2003 | β |
| M129V variation in the prion protein may influence cognitive performance. | Rujescu D et al. | β | 2003 | β |
| Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies. | Faraone SV et al. | β | 2003 | β |
| Brain and cognitive evolution: forms of modularity and functions of mind. | Geary DC et al. | β | 2002 | β |
| Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia. | Cannon TD et al. | β | 2002 | β |
| Genetic influence on quantitative features of neocortical architecture. | Kaschube M et al. | β | 2002 | β |
| Mapping genetic influences on human brain structure. | Thompson P et al. | β | 2002 | β |
| Normal neuroanatomical variation in the human brain: an MRI-volumetric study. | Allen JS et al. | β | 2002 | β |
| Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins. | Carmelli D et al. | β | 2002 | β |
| The association between brain volume and intelligence is of genetic origin. | Posthuma D et al. | β | 2002 | β |
| Twin-singleton differences in brain structure using structural equation modelling. | Hulshoff Pol HE et al. | β | 2002 | β |