The changing impact of genes and environment on brain development during childhood and adolescence: initial findings from a neuroimaging study of pediatric twins.
paper
Cited
Public
- Authors
- Lenroot, Rhoshel K; Giedd, Jay N
- Year
- 2008
- Journal
- Development and psychopathology
- PMID
- 18838036
- DOI
- 10.1017/S0954579408000552
- PMCID
- PMC2892674
Human brain development is created through continuing complex interactions of genetic and environmental influences. The challenge of linking specific genetic or environmental risk factors to typical or atypical behaviors has led to interest in using brain structural features as an intermediate phenotype. Twin studies in adults have found that many aspects of brain anatomy are highly heritable, demonstrating that genetic factors provide a significant contribution to variation in brain structures. Less is known about the relative impact of genes and environment while the brain is actively developing. We summarize results from the ongoing National Institute of Mental Health child and adolescent twin study that suggest that heritability of different brain areas changes over the course of development in a regionally specific fashion. Areas associated with more complex reasoning abilities become increasingly heritable with maturation. The potential mechanisms by which gene-environment interactions may affect heritability values during development is discussed.
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| Neuroimaging genetics and developmental psychopathology: A systematic review. | Cheek CL et al. | — | 2025 | → |
| Prenatal psychological distress and neurodevelopmental trajectories in the first 3 years: a systematic review. | De Domenico C et al. | — | 2025 | → |
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| Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis. | Lim L et al. | — | 2025 | → |
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| Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings. | Constant-Varlet C et al. | — | 2024 | → |
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| Genetic underpinnings of brain structural connectome for young adults. | Zhao Y et al. | — | 2023 | → |
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| Increasing diversity in connectomics with the Chinese Human Connectome Project. | Ge J et al. | — | 2023 | → |
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| Proportional intracranial volume correction differentially biases behavioral predictions across neuroanatomical features, sexes, and development. | Dhamala E et al. | — | 2022 | → |
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| Multimodal Neurophysiological and Neuroimaging Evidence of Genetic Influence on Motor Control: A Case Report of Monozygotic Twins. | Papadopoulou M et al. | — | 2021 | → |
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| Cross-sectional volumes and trajectories of the human brain, gray matter, white matter and cerebrospinal fluid in 9,473 typically aging adults | Irimia A | — | 2020 | — |
| Genetic and Environmental Influences on Lobar Brain Structures in Twins With Autism. | Hegarty JP et al. | — | 2020 | → |
| Identification of novel loci associated with infant cognitive ability. | Sun R et al. | — | 2020 | → |
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| Sex-related differences in intrinsic brain dynamism and their neurocognitive correlates. | de Lacy N et al. | — | 2019 | → |
| Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia. | Caverzasi E et al. | — | 2018 | → |
| Exercise of Varying Durations: No Acute Effects on Cognitive Performance in Adolescents. | van den Berg V et al. | — | 2018 | → |
| Factors affecting child development assessed by the Ages and Stages Questionnaire (ASQ) in an Arabic speaking population. | Sinno D et al. | — | 2018 | → |
| Genetic influences on neonatal cortical thickness and surface area. | Jha SC et al. | — | 2018 | → |
| Grey matter volume and thickness abnormalities in young people with a history of childhood abuse. | Lim L et al. | — | 2018 | → |
| Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategies. | Patel S et al. | — | 2018 | → |
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| Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure. | Gross LA et al. | — | 2018 | → |
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| Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging. | Keuken MC et al. | — | 2018 | → |
| At least eighty percent of brain grey matter is modifiable by physical activity: A review study. | Batouli SAH et al. | — | 2017 | → |
| E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration. | Upadhyay A et al. | — | 2017 | → |
| Environmental enrichment mitigates the impact of ancestral stress on motor skill and corticospinal tract plasticity. | McCreary JK et al. | — | 2016 | → |
| Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions. | Nam KW et al. | — | 2015 | → |
| Brain electrical activities of dancers and fast ball sports athletes are different. | Ermutlu N et al. | — | 2015 | → |
| Gender modulates the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2015 | → |
| Genetics and brain morphology. | Strike LT et al. | — | 2015 | → |
| Neuroplasticity Changes of Rat Brain by Musical Stimuli during Fetal Period. | Sheikhi S et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD. | Kadziela-Olech H et al. | — | 2015 | → |
| Social skills in pediatric epilepsy: important but understudied. | Caplan R | — | 2015 | → |
| Using Sibling Designs to Understand Neurodevelopmental Disorders: From Genes and Environments to Prevention Programming. | Wade M et al. | — | 2015 | → |
| Applying imaging genetics to ADHD: the promises and the challenges. | Wu Z et al. | — | 2014 | → |
| Cognitive ability changes and dynamics of cortical thickness development in healthy children and adolescents. | Burgaleta M et al. | — | 2014 | → |
| Development and heritability of subcortical brain volumes at ages 9 and 12. | Swagerman SC et al. | — | 2014 | → |
| Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis. | Lim L et al. | — | 2014 | → |
| Parent-offspring similarity for drinking: a longitudinal adoption study. | McGue M et al. | — | 2014 | → |
| Postnatal development of the hippocampus in the Rhesus macaque (Macaca mulatta): a longitudinal magnetic resonance imaging study. | Hunsaker MR et al. | — | 2014 | → |
| Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children. | Douet V et al. | — | 2014 | → |
| The heritability of volumes of brain structures and its relationship to age: a review of twin and family studies. | Batouli SA et al. | — | 2014 | → |
| Autism as the Early Closure of a Neuroplastic Critical Period Normally Seen in Adolescence. | Berger JM et al. | — | 2013 | → |
| Structural and functional brain correlates of behavioral outcomes during adolescence. | Nosarti C | — | 2013 | → |
| Epigenetic regulation of fetal brain development and neurocognitive outcome. | Petanjek Z et al. | — | 2012 | → |
| Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. | Li D et al. | — | 2012 | → |
| Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies. | Blokland GA et al. | — | 2012 | → |
| Genetic contributions to the midsagittal area of the corpus callosum. | Phillips KA et al. | — | 2012 | → |
| Mapping genetic and environmental influences on cortical surface area of pediatric twins. | Yoon U et al. | — | 2012 | → |
| Neurodevelopmental model of schizophrenia: update 2012. | Rapoport JL et al. | — | 2012 | → |
| Sexing the baby: Part 1--What do we really know about sex differentiation in the first three years of life? | Fausto-Sterling A et al. | — | 2012 | → |
| Training the brain: fact and fad in cognitive and behavioral remediation. | Rabipour S et al. | — | 2012 | → |
| White matter heritability using diffusion tensor imaging in neonatal brains. | Geng X et al. | — | 2012 | → |
| Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder. | Rapoport JL et al. | — | 2011 | → |
| COMT gene polymorphism and corpus callosum morphometry in preterm born adults. | Dutt A et al. | — | 2011 | → |
| Effects of early life stress on cognitive and affective function: an integrated review of human literature. | Pechtel P et al. | — | 2011 | → |
| Emergence of a Gene x socioeconomic status interaction on infant mental ability between 10 months and 2 years. | Tucker-Drob EM et al. | — | 2011 | → |
| Genetic and environmental influences on structural variability of the brain in pediatric twin: deformation based morphometry. | Yoon U et al. | — | 2011 | → |
| Heritability of working memory brain activation. | Blokland GA et al. | — | 2011 | → |
| Individual differences in local gray and white matter volumes reflect differences in temperament and character: a voxel-based morphometry study in healthy young females. | Van Schuerbeek P et al. | — | 2011 | → |
| Twin-singleton differences in neonatal brain structure. | Knickmeyer RC et al. | — | 2011 | → |
| Understanding the effects of stimulant medications on cognition in individuals with attention-deficit hyperactivity disorder: a decade of progress. | Swanson J et al. | — | 2011 | → |
| What can emerging cortical face networks tell us about mature brain organisation? | Cohen Kadosh K | — | 2011 | → |
| Genetic and environmental contributions to neonatal brain structure: A twin study. | Gilmore JH et al. | — | 2010 | → |
| Imaging genetics in ADHD. | Durston S | — | 2010 | → |
| Lateralized genetic and environmental influences on human brain morphology of 8-year-old twins. | Yoon U et al. | — | 2010 | → |
| Neuroanatomic alterations and social and communication deficits in monozygotic twins discordant for autism disorder. | Mitchell SR et al. | — | 2009 | → |
| Understanding genes, environment and their interaction in attention-deficit hyperactivity disorder: is there a role for neuroimaging? | Plomp E et al. | — | 2009 | → |