Genetic analyses of DSM-IV nicotine withdrawal in adult twins.
- Authors
- Pergadia, Michele L; Heath, Andrew C; Martin, Nicholas G; Madden, Pamela A F
- Year
- 2006
- Journal
- Psychological medicine
- PMID
- 16749946
- DOI
- 10.1017/S0033291706007495
BACKGROUND: We examined whether there are genetic influences on nicotine withdrawal, and whether there are genetic factors specific to nicotine withdrawal, after controlling for factors responsible for risk of progression beyond experimentation with cigarettes and for quantity smoked (average number of cigarettes per day at peak lifetime use). METHOD: Epidemiologic and genetic analyses were conducted using telephone diagnostic interview data from young adult Australian twins reporting any cigarette use (3026 women, 2553 men; mean age 30 years). RESULTS: Genetic analysis of the eight symptoms of DSM-IV nicotine withdrawal suggests heritability is intermediate for most symptoms (26-43%), and similar in men and women. The exceptions were depressed mood upon withdrawal, which had stronger additive genetic influences in men (53%) compared to women (29%), and decreased heart rate, which had low heritability (9%). Although prevalence rates were substantially lower for DSM-IV nicotine withdrawal syndrome (15.9%), which requires impairment, than for the DSM-IV nicotine dependence withdrawal criterion (43.6%), heritability was similar for both measures: as high as 47%. Genetic modeling of smoking more than 1 or 2 cigarettes lifetime ('progression'), quantity smoked and nicotine withdrawal found significant genetic overlap across all three components of nicotine use/dependence (genetic correlations = 0.53-0.76). Controlling for factors associated with risk of cigarette smoking beyond experimentation and quantity smoked, evidence for genetic influences specific to nicotine withdrawal (up to 23% of total variance) remained. CONCLUSIONS: Our results suggest that at least some individuals become 'hooked' or progress in the smoking habit, in part, because of a vulnerability to nicotine withdrawal.
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| Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use. | Prom-Wormley E et al. | — | 2015 | → |
| NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. | Bidwell LC et al. | — | 2015 | → |
| Nicotine withdrawal. | McLaughlin I et al. | — | 2015 | → |
| Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines. | Nesil T et al. | — | 2015 | → |
| Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment. | Ashare RL et al. | — | 2014 | → |
| Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers. | Lazary J et al. | — | 2014 | → |
| Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats. | Wang T et al. | — | 2014 | → |
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| Neuroadaptation in nicotine addiction: update on the sensitization-homeostasis model. | DiFranza JR et al. | — | 2012 | → |
| Parent, sibling and peer influences on smoking initiation, regular smoking and nicotine dependence. Results from a genetically informative design. | Scherrer JF et al. | — | 2012 | → |
| Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. | Gold AB et al. | — | 2012 | → |
| Suicidal behavior, smoking, and familial vulnerability. | Scherrer JF et al. | — | 2012 | → |
| The co-occurring use and misuse of cannabis and tobacco: a review. | Agrawal A et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependence. | Agrawal A et al. | — | 2011 | → |
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| The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. | Lori A et al. | — | 2011 | → |
| A systematic review of the Diagnostic and Statistical Manual diagnostic criteria for nicotine dependence. | DiFranza J et al. | — | 2010 | → |
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| A testable prognostic model of nicotine dependence. | Ramoni RB et al. | — | 2009 | → |
| Constitutional mechanisms of vulnerability and resilience to nicotine dependence. | Hiroi N et al. | — | 2009 | → |
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| Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. | Benowitz NL | — | 2009 | → |
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| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| Assessing dimensions of nicotine dependence: an evaluation of the Nicotine Dependence Syndrome Scale (NDSS) and the Wisconsin Inventory of Smoking Dependence Motives (WISDM). | Piper ME et al. | — | 2008 | → |
| Early cannabis use and DSM-IV nicotine dependence: a twin study. | Agrawal A et al. | — | 2008 | → |
| Genes and cigarette smoking. | Munafò MR et al. | — | 2008 | → |
| Genetics of nicotine dependence and pharmacotherapy. | Lessov-Schlaggar CN et al. | — | 2008 | → |
| Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. | Portugal GS et al. | — | 2008 | → |
| Is there evidence for symptoms of cannabis withdrawal in the national epidemiologic survey of alcohol and related conditions? | Agrawal A et al. | — | 2008 | → |
| Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives. | Piper ME et al. | — | 2008 | → |
| Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? | Morley KI et al. | — | 2007 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |