Younger for longer: insulin signalling, immunity and ageing.
- Authors
- Amrit, Francis R G; May, Robin C
- Year
- 2010
- Journal
- Current aging science
- PMID
- 20735349
- DOI
- 10.2174/1874609811003030166
Genes, the environment and stochastic factors such as lifestyle are major contributors to the universally shared phenomenon of ageing. It is now clear that these different inputs act through evolutionarily conserved pathways to regulate lifespan in a wide range of animals. Among several such pathways, the IIS [Insulin/IGF (Insulin -like growth factor)- like signalling] pathway, initially identified in the roundworm, Caenorhabditis elegans, is the most significant modulator of ageing. Consisting of a PI 3 kinase-signalling cascade downstream of a transmembrane insulin-like growth factor receptor, this pathway ultimately regulates the activity of a transcription factor with a huge repertoire of transcriptional outputs. The effect of this is that the IIS pathway co-ordinately controls several processes, including immunity and stress resistance,which in tandem seem to regulate longevity. Since both the function and molecular architecture of the IIS pathway is conserved from yeast to mammals, this coordinate regulation appears to be a general feature of the ageing processes in animals. Here we review the evolutionary conservation of the IIS pathway and discuss this in relation to recent findings on the molecular basis of ageing. We also reflect on the impact and significance of the evolutionary diversification of this pathway and propose a model for how such differences could explain both inter and intra-species differences in ageing.
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| Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling. | Bridi JC et al. | β | 2015 | β |
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| Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors. | Snell TW et al. | β | 2014 | β |
| The C. elegans healthspan and stress-resistance assay toolkit. | Keith SA et al. | β | 2014 | β |
| The C. elegans lifespan assay toolkit. | Amrit FR et al. | β | 2014 | β |
| Aging biology: a new frontier for drug discovery. | Verdaguer E et al. | β | 2012 | β |
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| Longevity candidate genes and their association with personality traits in the elderly. | Luciano M et al. | β | 2012 | β |