Longevity candidate genes and their association with personality traits in the elderly.

paper Primary Public

Authors: Luciano, Michelle; Lopez, Lorna M; de Moor, Marleen H M; Harris, Sarah E; Davies, Gail; Nutile, Teresa; Krueger, Robert F; Esko, Tõnu; Schlessinger, David; Toshiko, Tanaka; Derringer, Jaime L; Realo, Anu; Hansell, Narelle K; Pergadia, Michele L; Pesonen, Anu-Katriina; Sanna, Serena; Terracciano, Antonio; Madden, Pamela A F; Penninx, Brenda; Spinhoven, Philip; Hartman, Catherina A; Oostra, Ben A; Janssens, A Cecile J W; Eriksson, Johan G; Starr, John M; Cannas, Alessandra; Ferrucci, Luigi; Metspalu, Andres; Wright, Margeret J; Heath, Andrew C; van Duijn, Cornelia M; Bierut, Laura J; Raikkonen, Katri; Martin, Nicholas G; Ciullo, Marina; Rujescu, Dan; Boomsma, Dorret I; Deary, Ian J
Year: 2012
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 22213687
DOI: 10.1002/ajmg.b.32013
PMCID: PMC3583011

#	Section	Preview
0	Materials and Methods — Subjects – LBC1936	All participants were born in 1936 and had taken part in the Scottish Mental Survey of 1947; they…
1	Materials and Methods — Subjects – LBC1936	Scale (HADS) [19]. The personality traits of the Five Factor model (see Introduction) were measured…
2	Materials and Methods — SNP selection	SNPs with a minor allele frequency greater than .05 were selected using Tagger [22] in Haploview v…
3	Materials and Methods — Genotyping	Genomic DNA was isolated from whole blood by standard procedure at the WTCRF Genetics Core, Western…
4	Materials and Methods — Genotype data	The mean genotyping rate was 99% (range 92%-100%) and minor allele frequencies (MAF) were > 0.04…
5	Materials and Methods — Statistical Analysis and Power	Association tests were performed for individual SNPs in PLINK [26] using the regression option…
6	Materials and Methods — Replication Cohorts — Personality Traits	Eleven cohorts were available in which to replicate any associations for NEO personality measures.…
7	Materials and Methods — Replication Cohorts — Anxiety and Depression Traits	HADS data were available in an independent cohort of 517 participants from the Lothian region, born…
8	Results	The anxiety and depression scores from the HADS were negatively skewed and were square root…
9	Results	The results of the association tests for personality and psychological distress measures in the…
10	Results	Ten SNPs were nominally significant for depression, with all of these located in SYNJ2 (more than…
11	Results	Across all traits, standardised coefficients for nominally significant associations ranged between…
12	Results	the mean ages were 63.4 ±3 years (HBCS) and 68.5 ±17 years (BSA). The allele effects in these…
13	Discussion	A priori evidence of an association between personality and longevity [4] led us to test the…
14	Discussion	Due to their increased association with longevity, conscientiousness and neuroticism were especially…
15	Discussion	[34]. While this is aligned with our findings of association with depression and neuroticism, our…
16	Discussion	The only gene that has been tested previously for association with traits relevant to our study was…
17	Discussion	Our SNPs were chosen using information from HapMap, but one study which re-sequenced longevity…
18	Figure 1	The linkage disequilibrium structure (including r2) for the region genotyped in SYNJ2 in the…

Name	Type
A allele	cohort
AFG3L2 local	gene
age	phenotype
agreeableness	phenotype
agreeableness scores local	phenotype
Anti-depressant local	drug
anxiety	phenotype
bipolar disorder	phenotype
BLSA	cohort
BSA local	cohort
Cilento local	cohort
cingulate cortex	anatomy
conscientiousness	phenotype
depression	phenotype
depression scores	phenotype
EGPUT local	cohort
emotional stability	phenotype
ERF	gene
Five Factor model	phenotype
Five Factor model traits local	phenotype
FRAP1 local	gene
Germany	cohort
HADS local	phenotype
HADS anxiety local	phenotype
HapMap	cohort
HAPMAP II local	drug
HBCS local	cohort
healthy old adults local	cohort
Illumina Human610-Quadv1 Chip local	drug
IPIP	drug
IPIP agreeableness local	phenotype
IPIP Big-Five 50-item inventory local	phenotype
IPIP conscientiousness local	phenotype
IPIP emotional stability local	phenotype
IPIP neuroticism local	phenotype
LBC1921 local	cohort
LBC1936	cohort
longevity	phenotype
Lothian Birth Cohort 1936	cohort
major depressive disorder	phenotype
Mat1a	gene
MAT2A local	gene
NAG/IRPG local	cohort
NEO	phenotype
NEO agreeableness local	phenotype
NEO conscientiousness local	phenotype
NEO extraversion local	phenotype
NEO-FFI local	phenotype
NEO Five-Factor Inventory local	phenotype
NEO openness to experience local	phenotype
NEO personality measures local	phenotype
nerve terminals local	anatomy
neuroticism	phenotype
neuroticism factor	phenotype
NTR/NESDA local	cohort
older cohort	cohort
overall survival	phenotype
participants	cohort
personality traits	phenotype
Plink	drug
psychological distress	phenotype
psychological distress measures local	phenotype
QIMR	cohort
Replication sample (N>17000) local	cohort
rs10046389 local	variant
rs10455936 local	variant
rs12202135 local	variant
rs1750043 local	variant
rs2254562 local	variant
rs2502601 local	variant
rs350292 local	variant
rs9459093 local	variant
SAGE	cohort
Sardinia	cohort
straightforwardness facet local	phenotype
SYNJ1	gene
SYNJ2 local	gene
temporal cortex	anatomy
women	cohort
younger cohort	cohort

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