A priori evidence of an association between personality and longevity [4] led us to test the association between a specific set of longevity candidate genes—established via a functional genomics study—and personality, anxiety and depression measures. Of the six genes tested, SYNJ2 showed a heightened number of SNPs that were nominally significant at an uncorrected level for measures of agreeableness and depression, and to a lesser extent, neuroticism.
