SNPs with a minor allele frequency greater than .05 were selected using Tagger [22] in Haploview v 4.1 [23] based on the Hapmap CEPH population (Release 22) data. Using pairwise tagging (r2=.80), 70 SNPs tagged haplotypes from the specific gene regions and 5kb either side of the gene, although one of these SNPs was excluded due to high linkage disequilibrium with another tagged SNP. They served as direct proxies to all other untyped SNPs in the six genes because they are highly correlated with one another. Non-synonymous SNPs were also included as haplotype-tagging SNPs. The UCSC genome browser [24] was used to identify non-synonymous SNPs—rs2502601 in exon 27 of SYNJ2 a missense substitution (G=Gly, A=Glu, Glu1468Gly) and rs2254562 in exon 8 of SYNJ1 a missense substitution (G=Arg, A=Lys, Lys295Arg), giving 70 SNPs in total.
