Across all traits, standardised coefficients for nominally significant associations ranged between .06 and .11. A reduced set of SNPs which were nominally associated with both NEO and IPIP scales or with both psychological distress and emotional stability (and therefore deemed more reliable associations) in the LBC1936 are shown in Table 2. Replication of these SNPs was sought in independent cohorts. Table 3 shows the replication results for the personality traits. One of these SNPs, rs350292 (located in intron 18 of SYNJ2; MAF: 0.11), was significantly associated with agreeableness in the older cohorts (p = .0059), and at a reduced level in the combined older and younger cohorts meta-analysis. Within the eleven individual cohorts tested, nominal significance was observed in three of these (ERF, p = .049; HBCS, p = .038; BSA, p = .048), with two being ageing cohorts where the mean ages were 63.4 ±3 years (HBCS) and 68.5 ±17 years (BSA). The allele effects in these cohorts were in the same direction as the original association in LBC1936: the unstandardised regression coefficient was −.67 in the older cohort
