Ten SNPs were nominally significant for depression, with all of these located in SYNJ2 (more than expected by chance); the most significant SNP was rs10046389 (p = .004) with a MAF of 0.40. Another of these SNPs (rs1750043) was also associated with anxiety (p = .01; MAF: 0.48). High conscientiousness and low neuroticism have been especially linked with longevity, but the association results were predominantly null for conscientiousness (three SNPs nominally associated with NEO and one non-overlapping SNP with IPIP). Eight SNPs were associated with IPIP emotional stability, two of which (rs10455936, MAF, 0.22; rs9459093, MAF, 0.43) located in SYNJ2 overlapped with significant SNPs for NEO neuroticism. Because a large number of SNPs (i.e., 44) was typed in SYNJ2 the linkage disequilibrium between them is shown in Figure 1; note that 24 independent SNPs were derived by SNP Spectral Decomposition.
